PDT Research Institute, School of Nano System Engineering, Inje University, Gimhae, Korea.
Int J Mol Sci. 2008 May;9(5):864-871. doi: 10.3390/ijms9050864. Epub 2008 May 23.
For possible future use in Photodynamic Therapy (PDT) and/or Photothermal Therapy (PTT) of cancer and screening of cancer cells a new type of ionic liquid photosensitizer -Cholinium-Purpurin-18 (Chol-Pu-18) - was synthesized and small gold (Au) nanoparticles, stabilized by this photosensitizer were prepared without adding any particular reducing agents and CTAB. UV-Vis spectroscopy and Transmission Electron Microscopy (TEM) were used for characterization of the nanoparticles and FAB-MS and NMR of the ionic liquid choline hydroxide, purpurin carboxylate and their ionic liquid type of photosensitizer were obtained.
为了可能在未来用于癌症的光动力疗法 (PDT) 和/或光热疗法 (PTT) 以及癌细胞筛查,合成了一种新型的离子液体光敏剂 - 胆碱-紫红素-18 (Chol-Pu-18) -,并在不添加任何特殊还原剂和 CTAB 的情况下制备了由该光敏剂稳定的小金 (Au) 纳米粒子。使用紫外可见光谱和透射电子显微镜 (TEM) 对纳米粒子进行了表征,并通过 FAB-MS 和 NMR 获得了离子液体胆碱氢氧化物、紫红素羧酸及其离子液体型光敏剂的结构信息。