治疗相关的髓系肿瘤
Therapy-related myeloid neoplasms.
作者信息
Larson Richard A
机构信息
Department of Medicine and Cancer Research Center, University of Chicago, Chicago, Illinois, USA.
出版信息
Haematologica. 2009 Apr;94(4):454-9. doi: 10.3324/haematol.2008.005157.
Abstract
Therapy-related myeloid neoplasm is the term recently proposed by the World Health Organization to cover the spectrum of malignant disorders previously described as therapy-related myelodysplastic syndrome or therapy-related acute myeloid leukemia. In this perspective article, Dr. Larson explores the important question of whether the poor prognosis of these conditions reflects t-MN per se or, rather, associated findings such as complex cytogenetics that are also seen, although less frequently, in de novo myeloid neoplasms. See related article on page 542.
摘要
治疗相关髓系肿瘤是世界卫生组织最近提出的术语，用以涵盖先前被描述为治疗相关骨髓增生异常综合征或治疗相关急性髓系白血病的一系列恶性疾病。在这篇观点文章中，拉尔森博士探讨了一个重要问题，即这些病症的不良预后是反映了治疗相关髓系肿瘤本身，还是反映了诸如复杂细胞遗传学等相关发现，这些发现也可见于原发性髓系肿瘤，只是出现频率较低。见第542页的相关文章。
相似文献
1
Therapy-related myeloid neoplasms.治疗相关的髓系肿瘤
Haematologica. 2009 Apr;94(4):454-9. doi: 10.3324/haematol.2008.005157.
2
Inclusion of secondary chronic myelomonocytic leukemia and myeloproliferative disease, unclassifiable, in classification of pediatric myeloproliferative disorders.
J Pediatr Hematol Oncol. 2006 Oct;28(10):700-1. doi: 10.1097/01.mph.0000243643.13369.63.
3
Second malignancies after chemotherapy and transplantation.
Crit Rev Oncol Hematol. 1993 Apr;14(2):107-25. doi: 10.1016/1040-8428(93)90067-e.
4
Therapy-related myeloid neoplasms in lymphoma survivors: Reducing risks.淋巴瘤幸存者相关治疗相关性髓系肿瘤：降低风险。
Best Pract Res Clin Haematol. 2019 Mar;32(1):47-53. doi: 10.1016/j.beha.2019.02.008. Epub 2019 Feb 16.
5
Myeloid neoplasms secondary to plasma cell myeloma: an intrinsic predisposition or therapy-related phenomenon? A clinicopathologic study of 41 cases and correlation of cytogenetic features with treatment regimens.继发于浆细胞骨髓瘤的骨髓增生性肿瘤：是内在易感性还是治疗相关现象？41 例临床病理研究及细胞遗传学特征与治疗方案的相关性。
Am J Clin Pathol. 2012 Dec;138(6):855-66. doi: 10.1309/AJCPOP7APGDT9JIU.
6
Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation.儿童继发性急性髓系白血病，既往接受过烷化剂、嵌入型拓扑异构酶II抑制剂及放疗。
J Clin Oncol. 1993 Jun;11(6):1039-45. doi: 10.1200/JCO.1993.11.6.1039.
7
How much does 2016 WHO classification of myeloproliferative neoplasms affect the clinic?2016年世界卫生组织髓系增殖性肿瘤分类对临床有多大影响？
Expert Rev Hematol. 2019 Jul;12(7):473-476. doi: 10.1080/17474086.2019.1623019. Epub 2019 Jun 4.
8
Characteristics and outcomes of therapy-related myeloid neoplasms after treatment for multiple myeloma.多发性骨髓瘤治疗后治疗相关髓系肿瘤的特征与转归
Leuk Lymphoma. 2019 Dec;60(14):3577-3580. doi: 10.1080/10428194.2019.1633639. Epub 2019 Jul 8.
9
TP53 and therapy-related myeloid neoplasms.TP53 与治疗相关的髓系肿瘤。
Best Pract Res Clin Haematol. 2019 Mar;32(1):98-103. doi: 10.1016/j.beha.2019.02.009. Epub 2019 Feb 19.
10
[Therapy-related myeloid neoplasms].
Nihon Rinsho. 2012 Apr;70 Suppl 2:699-703.
引用本文的文献
1
Role of Population Based Studies in Advancing our Knowledge of Myelodysplastic Syndromes.基于人群的研究在增进我们对骨髓增生异常综合征认识方面的作用。
Curr Hematol Malig Rep. 2025 Jan 17;20(1):6. doi: 10.1007/s11899-025-00750-5.
2
From regulation to deregulation of p53 in hematologic malignancies: implications for diagnosis, prognosis and therapy.从血液系统恶性肿瘤中p53的调控到去调控：对诊断、预后和治疗的影响
Biomark Res. 2024 Nov 14;12(1):137. doi: 10.1186/s40364-024-00676-9.
3
Characteristics and outcomes of patients with lymphoma who developed therapy-related acute myeloid leukemia or myelodysplastic syndrome - a retrospective analysis of the Polish Adult Leukemia Group.发生治疗相关急性髓系白血病或骨髓增生异常综合征的淋巴瘤患者的特征与结局——波兰成人白血病组的回顾性分析
Contemp Oncol (Pozn). 2024;28(2):149-157. doi: 10.5114/wo.2024.141727. Epub 2024 Jul 24.
4
Therapy-Related Myeloid Neoplasm: Biology and Mechanistic Aspects of Malignant Progression.治疗相关的髓系肿瘤：恶性进展的生物学和机制方面
Biomedicines. 2024 May 10;12(5):1054. doi: 10.3390/biomedicines12051054.
5
Latest Insights and Therapeutic Advances in Myelodysplastic Neoplasms.骨髓增生异常综合征的最新见解与治疗进展
Cancers (Basel). 2024 Apr 19;16(8):1563. doi: 10.3390/cancers16081563.
6
Genomic profiling of a metastatic anaplastic melanocytic neuroectodermal tumor arising from a mature thymic teratoma as part of a mediastinal germ cell tumor.对源自成熟胸腺瘤的转移性间变性黑色素性神经外胚层肿瘤进行基因组分析，该肿瘤是纵隔生殖细胞肿瘤的一部分。
Cold Spring Harb Mol Case Stud. 2023 May 9;9(2). doi: 10.1101/mcs.a006257. Print 2023 Apr.
7
The Secondary Myelodysplastic Neoplasms (MDS) Jigsaw.继发性骨髓增生异常肿瘤（MDS）拼图
Cancers (Basel). 2023 Feb 26;15(5):1483. doi: 10.3390/cancers15051483.
8
Therapy-related myeloid neoplasms following treatment for multiple myeloma-a single center analysis.治疗多发性骨髓瘤后的治疗相关髓系肿瘤：单中心分析。
Ann Hematol. 2022 May;101(5):1031-1038. doi: 10.1007/s00277-022-04775-1. Epub 2022 Mar 9.
9
Case Report: Myeloid Sarcoma Development During Treatment for B Cell Lymphoblastic Lymphoma in a Boy with KRAS/NRAS Gene Mutations.病例报告：一名患有KRAS/NRAS基因突变的男孩在B细胞淋巴母细胞淋巴瘤治疗期间发生髓系肉瘤
Onco Targets Ther. 2021 Jan 13;14:347-353. doi: 10.2147/OTT.S276912. eCollection 2021.
10
Risk factors for de novo and therapy-related myelodysplastic syndromes (MDS).新发和治疗相关骨髓增生异常综合征（MDS）的危险因素。
Cancer Causes Control. 2021 Mar;32(3):241-250. doi: 10.1007/s10552-020-01378-x. Epub 2021 Jan 4.
本文引用的文献
1
Risk factors for therapy-related myelodysplastic syndrome and acute myeloid leukemia treated with allogeneic stem cell transplantation.接受异基因干细胞移植治疗的治疗相关骨髓增生异常综合征和急性髓系白血病的危险因素。
Haematologica. 2009 Apr;94(4):542-9. doi: 10.3324/haematol.2008.000927. Epub 2009 Mar 10.
2
Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders.5号染色体长臂缺失（del(5q)）的候选基因EGR1单倍剂量不足会导致骨髓疾病的发生。
Blood. 2007 Jul 15;110(2):719-26. doi: 10.1182/blood-2007-01-068809. Epub 2007 Apr 9.
3
Alternative genetic pathways and cooperating genetic abnormalities in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia.治疗相关骨髓增生异常综合征和急性髓系白血病发病机制中的替代遗传途径及协同遗传异常
Leukemia. 2006 Nov;20(11):1943-9. doi: 10.1038/sj.leu.2404381. Epub 2006 Sep 21.
4
Autologous stem cell transplantation for therapy-related acute myeloid leukemia and myelodysplastic syndrome.自体干细胞移植治疗相关性急性髓系白血病和骨髓增生异常综合征。
Bone Marrow Transplant. 2006 Jan;37(2):183-9. doi: 10.1038/sj.bmt.1705226.
5
The molecular basis of leukemia.白血病的分子基础。
Hematology Am Soc Hematol Educ Program. 2004:80-97. doi: 10.1182/asheducation-2004.1.80.
6
Prognosis in therapy-related acute myeloid leukemia and impact of karyotype.治疗相关急性髓系白血病的预后及核型的影响
J Clin Oncol. 2004 Jun 15;22(12):2510-1. doi: 10.1200/JCO.2004.99.301.
7
Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation.器官移植后急性髓系白血病/骨髓增生异常综合征中DNA错配修复缺陷
Blood. 2004 Aug 1;104(3):822-8. doi: 10.1182/blood-2003-11-3938. Epub 2004 Apr 15.
8
Karyotype is an independent prognostic parameter in therapy-related acute myeloid leukemia (t-AML): an analysis of 93 patients with t-AML in comparison to 1091 patients with de novo AML.核型是治疗相关性急性髓系白血病（t-AML）的一个独立预后参数：对93例t-AML患者与1091例初发AML患者的分析
Leukemia. 2004 Jan;18(1):120-5. doi: 10.1038/sj.leu.2403187.
9
Therapy-related acute promyelocytic leukemia.治疗相关的急性早幼粒细胞白血病
J Clin Oncol. 2003 Jun 1;21(11):2123-37. doi: 10.1200/JCO.2003.09.072.
10
Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series.306例治疗相关的骨髓增生异常综合征和髓系白血病患者的临床细胞遗传学关联：芝加哥大学研究系列
Blood. 2003 Jul 1;102(1):43-52. doi: 10.1182/blood-2002-11-3343. Epub 2003 Mar 6.
Zotero 插件