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严重肝外伤的肝移植:单中心经验

Liver transplantation for severe hepatic trauma: experience from a single center.

作者信息

Delis Spiros G, Bakoyiannis Andreas, Selvaggi Gennaro, Weppler Debbie, Levi David, Tzakis Andreas G

机构信息

Department of Surgery, Division of Transplantation, University of Miami Miller School of Medicine, Miami, FL 33101, USA.

出版信息

World J Gastroenterol. 2009 Apr 7;15(13):1641-4. doi: 10.3748/wjg.15.1641.

Abstract

Liver transplantation has been reported in the literature as an extreme intervention in cases of severe and complicated hepatic trauma. The main indications for liver transplant in such cases were uncontrollable bleeding and postoperative hepatic insufficiency. We here describe four cases of orthotopic liver transplantation after penetrating or blunt liver trauma. The indications were liver failure, extended liver necrosis, liver gangrene and multiple episodes of gastrointestinal bleeding related to portal hypertension, respectively. One patient died due to postoperative cerebral edema. The other three patients recovered well and remain on immunosuppression. Liver transplantation should be considered as a saving procedure in severe hepatic trauma, when all other treatment modalities fail.

摘要

肝脏移植在文献中被报道为严重复杂肝外伤病例的一种极端干预措施。此类病例中肝移植的主要指征是无法控制的出血和术后肝功能不全。我们在此描述4例穿透性或钝性肝外伤后原位肝移植的病例。指征分别为肝衰竭、广泛性肝坏死、肝坏疽以及与门静脉高压相关的多次胃肠道出血。1例患者因术后脑水肿死亡。其他3例患者恢复良好,仍在接受免疫抑制治疗。当所有其他治疗方式均失败时,肝移植应被视为严重肝外伤的一种挽救性手术。

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