Veldhuijzen van Zanten Jet J C S, Carroll Douglas, Ring Christopher
School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK.
Br J Health Psychol. 2009 Nov;14(Pt 4):805-16. doi: 10.1348/135910709X425734. Epub 2009 Apr 1.
In women, variation in the incidence of myocardial infarction (MI) has been reported with phase of the menstrual cycle. Mental stress-induced rheological and haemodynamic perturbations have been implicated in the triggering of MI. This study examined cardiovascular reactions to mental stress across the menstrual cycle, as a factor contributing to the known variation between the menstrual cycle phases in MI incidence.
Rheological and haemodynamic activity during rest and a prolonged mental stress task were assessed in 12 women during the follicular and luteal phases of the menstrual cycle.
The stress task increased haematocrit, colloid osmotic pressure, blood pressure and heart rate, and decreased heart rate variability and R-wave to pulse interval. However, there were no effects of menstrual phase on rheological or haemodynamic function at rest or in response to mental stress. There were also no moderating menstrual cycle effects for the rheological or haemodynamic reactions over time to this prolonged stress task.
Our findings do not support the hypothesis that variations in reactions to mental stress can explain the reported variations in risk for MI across the menstrual cycle.
有报道称，女性心肌梗死（MI）的发病率会随月经周期阶段而变化。精神压力引起的流变学和血流动力学紊乱被认为与MI的触发有关。本研究考察了整个月经周期中心血管系统对精神压力的反应，这是导致MI发病率在月经周期各阶段存在已知差异的一个因素。
在月经周期的卵泡期和黄体期，对12名女性在静息状态和长时间精神压力任务期间的流变学和血流动力学活动进行了评估。
压力任务使血细胞比容、胶体渗透压、血压和心率升高，使心率变异性和R波至脉搏间期降低。然而，月经周期阶段对静息状态下或对精神压力反应时的流变学或血流动力学功能没有影响。对于这项长时间压力任务，随着时间推移，流变学或血流动力学反应也没有受到月经周期的调节作用。
我们的研究结果不支持以下假设，即对精神压力的反应差异可以解释所报道的月经周期各阶段MI风险的差异。
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