C57BL/6和BALB/c小鼠对MPTP的品系特异性敏感性具有年龄依赖性。

Strain-specific sensitivity to MPTP of C57BL/6 and BALB/c mice is age dependent.

作者信息

Filipov Nikolay M, Norwood Allison B, Sistrunk Shannon C

机构信息

Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi, USA.

出版信息

Neuroreport. 2009 May 6;20(7):713-7. doi: 10.1097/WNR.0b013e32832aa95b.

DOI:10.1097/WNR.0b013e32832aa95b

PMID:19349914

Abstract

Administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to adult (2-month to 4-month-old) male C57BL/6 mice (MPTP-sensitive) is a valuable Parkinson's disease model. At comparable age, other strains, such as BALB/c, are minimally affected by MPTP (MPTP-resistant). However, the maintenance of resistance to MPTP throughout aging in MPTP-resistant strains has not been studied. Here, we show that, as previously reported, 1-month and 18-month-old C57BL/6 mice are least and most sensitive to MPTP, respectively. MPTP, as expected, did not affect the younger (1-month and 3-month-old) BALB/c mice, but it markedly decreased striatal dopamine in the older (10-month and 18-month-old) BALB/c mice. These data suggest that the sensitivity to MPTP is age dependent and that mice from an MPTP-resistant strain lose their resistance as they age.

摘要

给成年（2至4月龄）雄性C57BL/6小鼠（对MPTP敏感）注射MPTP（1-甲基-4-苯基-1,2,3,6-四氢吡啶）是一种有价值的帕金森病模型。在相同年龄，其他品系，如BALB/c，受MPTP的影响极小（对MPTP有抗性）。然而，尚未研究过对MPTP有抗性的品系在整个衰老过程中对MPTP抗性的维持情况。在此，我们表明，如先前报道的那样，1月龄和18月龄的C57BL/6小鼠分别对MPTP最不敏感和最敏感。正如预期的那样，MPTP对较年轻的（1月龄和3月龄）BALB/c小鼠没有影响，但它显著降低了较年长的（10月龄和18月龄）BALB/c小鼠纹状体中的多巴胺。这些数据表明，对MPTP的敏感性与年龄有关，并且来自对MPTP有抗性品系的小鼠随着年龄增长会失去其抗性。