产生螺旋手性的新型空间驱动模式。

New sterically driven mode for generation of helical chirality.

作者信息

Ueki Hisanori, Soloshonok Vadim A

机构信息

Department of Chemistry and Biochemistry, The University of Oklahoma, Norman, Oklahoma 73019, USA.

出版信息

Org Lett. 2009 Apr 16;11(8):1797-800. doi: 10.1021/ol900357d.

DOI:10.1021/ol900357d

PMID:19354321

Abstract

The presented results and the available literature data convincingly suggest that there is a new sterically driven mechanism for the formation of supramolecular helicity in the solid state. This mechanism requires the presence of sterically bulky groups, such as tert-butyl, for which the spiral arrangement in uninterrupted hydrogen-bonding chains, serving as an axis for helical structure and maximizing the repulsive stereochemical interactions, provide for the most efficient, spatially economical accommodation of these groups in a crystallographic unit cell.

摘要

所呈现的结果以及现有的文献数据令人信服地表明，在固态中存在一种新的空间驱动机制来形成超分子螺旋性。这种机制需要存在空间上较大的基团，如叔丁基，对于这些基团而言，在不间断的氢键链中的螺旋排列，作为螺旋结构的轴并最大化排斥性立体化学相互作用，能在晶体学晶胞中为这些基团提供最有效、空间上最经济的容纳方式。