Ohman H, Tiitinen A, Halttunen M, Lehtinen M, Paavonen J, Surcel H-M
National Institute for Health and Welfare, Oulu, Finland.
J Infect Dis. 2009 May 1;199(9):1353-9. doi: 10.1086/597620.
Chronic inflammation induced by Chlamydia trachomatis can lead to tubal factor infertility (TFI). To investigate the genetic basis of chlamydial TFI and various manifestations of tubal damage, we studied functional polymorphisms in selected cytokine genes (IL-10 -1082 A/G, -819 T/C, and -592 A/C; IFN-gamma +874 T/A; TNF-alpha -308 G/A; TGF-beta1 codons 10 T/C and 25 G/C; and IL-6 -174 G/C) in 114 women with laparoscopically verified TFI (hereafter known as "cases") and in 176 controls. Evidence of past infection with C. trachomatis was demonstrated in 96 cases by use of a combined test for humoral and cell-mediated immune responses to chlamydial elementary bodies (EBs) and chlamydial heat-shock protein 60 antigens. We found that the IL-10 -1082 AA genotype and the TNF-alpha -308 A allele increased the risk of severe tubal damage in women with infertility associated with C. trachomatis (odds ratio [OR], 7.3 [95% confidence interval {CI}, 1.3-42] and 4.0 [95% CI, 1.0-16], respectively), suggesting that differences in these genes contribute to the wide spectrum of disease manifestations.
沙眼衣原体引起的慢性炎症可导致输卵管因素不孕症（TFI）。为了研究衣原体TFI的遗传基础以及输卵管损伤的各种表现，我们研究了114例经腹腔镜检查证实为TFI的女性（以下简称“病例”）和176例对照中选定细胞因子基因（IL-10 -1082 A/G、-819 T/C和-592 A/C；IFN-γ +874 T/A；TNF-α -308 G/A；TGF-β1密码子10 T/C和25 G/C；以及IL-6 -174 G/C）的功能多态性。通过对沙眼衣原体原体（EBs）和沙眼衣原体热休克蛋白60抗原的体液和细胞介导免疫反应的联合检测，在96例病例中证实了既往沙眼衣原体感染的证据。我们发现，IL-10 -1082 AA基因型和TNF-α -308 A等位基因增加了沙眼衣原体相关不孕症女性发生严重输卵管损伤的风险（优势比[OR]分别为7.3 [95%置信区间{CI}，1.3 - 42]和4.0 [95% CI，1.0 - 16]），表明这些基因的差异导致了疾病表现的广泛差异。
Zotero 插件