颗粒酶B：与老年人对流感疫苗接种的保护作用及增强的细胞毒性T淋巴细胞反应相关。
Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults.
作者信息
McElhaney Janet E, Ewen Catherine, Zhou Xin, Kane Kevin P, Xie Dongxu, Hager W David, Barry Mary Beth, Kleppinger Alison, Wang Yazhen, Bleackley R Chris
机构信息
Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, 06030, USA.
出版信息
Vaccine. 2009 Apr 21;27(18):2418-25. doi: 10.1016/j.vaccine.2009.01.136. Epub 2009 Mar 3.
Abstract
This study compared serum antibody titers and granzyme B (GrzB) levels in virus-stimulated peripheral blood mononuclear cells following influenza vaccination. Twelve of 239 older adults who subsequently developed laboratory-diagnosed influenza illness (LDI) had significantly lower GrzB levels compared to subjects without LDI (p=0.004). Eight subjects with LDI in the previous year showed an enhanced GrzB response to vaccination (p=0.02). Serum antibody titers following vaccination did not distinguish those older adults who developed LDI from those who did not. These results suggest that GrzB levels could be combined with antibody titers to more effectively predict vaccine efficacy in older adults.
摘要
本研究比较了流感疫苗接种后病毒刺激的外周血单个核细胞中的血清抗体滴度和颗粒酶B（GrzB）水平。在239名随后出现实验室确诊流感疾病（LDI）的老年人中，有12人的GrzB水平显著低于未患LDI的受试者（p=0.004）。前一年患过LDI的8名受试者对疫苗接种表现出增强的GrzB反应（p=0.02）。接种疫苗后的血清抗体滴度无法区分发生LDI的老年人和未发生LDI的老年人。这些结果表明，GrzB水平可与抗体滴度相结合，以更有效地预测老年人的疫苗效力。
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