Epstein Joel B, Güneri Pelin
Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, University of Illinois, Chicago, Illinois, USA.
Curr Opin Otolaryngol Head Neck Surg. 2009 Apr;17(2):79-87. doi: 10.1097/moo.0b013e32832771da.
To review the literature on toluidine blue (TBlue) and to discuss the utility of TBlue in assessing and in clinical management of patients with oral mucosal lesions. The literature search was conducted using key word search including oral cancer, oral premalignant lesions, and TBlue and by selecting references from the articles reviewed.
The findings of this review show that TBlue has utility as an adjunct in the detection of premalignant and malignant oral mucosal lesions and in identifying high-risk areas of lesions for biopsy in patients at increased risk of cancer when evaluated by experienced healthcare workers.
TBlue positive lesions, whether histologically benign or with dysplasia, predict molecular change and behavior of oral premalignant lesions. TBlue may provide information regarding lesion margins, accelerate the decision to biopsy, guide biopsy site selection and treatment of oral premalignant and malignant lesions. These findings support the utility of TBlue as a clinical adjunct in assessment of oral mucosal lesions.
回顾有关甲苯胺蓝（TBlue）的文献，并讨论TBlue在评估口腔黏膜病变患者及临床管理中的应用。通过使用包括口腔癌、口腔癌前病变和TBlue在内的关键词搜索，并从所审查文章中选择参考文献来进行文献检索。
本综述结果表明，当由经验丰富的医护人员进行评估时，TBlue可作为辅助手段用于检测口腔黏膜癌前和恶性病变，以及识别癌症风险增加患者病变的高危活检区域。
TBlue阳性病变，无论组织学上为良性还是有发育异常，都可预测口腔癌前病变的分子变化和行为。TBlue可提供有关病变边缘的信息，加快活检决策，指导活检部位选择以及口腔癌前和恶性病变的治疗。这些发现支持TBlue作为评估口腔黏膜病变临床辅助手段的实用性。
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