加拿大钦西安族青年糖耐量受损及代谢综合征各组分的患病率

Prevalence of impaired glucose tolerance and the components of metabolic syndrome in Canadian Tsimshian Nation youth.

作者信息

Zorzi Alexandra, Wahi Gita, Macnab Andrew J, Panagiotopoulos Constadina

机构信息

Department of Pediatrics, University of British Columbia and British Columbia Children's Hospital, Vancouver, BC, Canada.

出版信息

Can J Rural Med. 2009 Spring;14(2):61-7.

PMID:19379629

Abstract

INTRODUCTION

Canadian Aboriginal people have been disproportionately affected by obesity and type 2 diabetes (T2D). Our objective was to determine the prevalence of obesity, glucose intolerance and the components of metabolic syndrome (MetS) in Tsimshian Nation youth living in 3 remote coastal communities.

METHODS

A medical history, anthropometric measurements and an oral glucose tolerance test were performed in youth aged 6-18 years. We defined "overweight" by a body mass index (BMI) at the 85th percentile or higher and "obese" by a BMI at the 95th percentile or higher, by age and sex. We used the International Diabetes Federation criteria for MetS.

RESULTS

Of the 224 eligible youth, 192 (85%) participated in the study. Nineteen percent were overweight, 26% were obese and 36% had central obesity (waist circumference > or = 90th percentile for age and sex). No new cases of T2D were identified. The prevalence of impaired fasting glucose (IFG 5.6-6.9 mmol/L) and impaired glucose tolerance (IGT 2-hr glucose 7.8-11.0 mmol/L) were 19.3% and 5.2%, respectively. Five of the 10 youth with IGT had a fasting glucose less than 5.6 mmol/L. The prevalence of MetS was 4.7% and increased to 8.3% when pediatric hypertension norms were applied.

CONCLUSION

Tsimshian Nation youth have a high prevalence of central obesity, impaired glucose homeostasis and other components of MetS. The oral glucose tolerance test may be a more appropriate screening test to identify IGT in Aboriginal youth.

摘要

引言

加拿大原住民受肥胖症和2型糖尿病（T2D）的影响尤为严重。我们的目标是确定居住在3个偏远沿海社区的辛姆西安族青年中肥胖症、葡萄糖耐量受损及代谢综合征（MetS）各组分的患病率。

方法

对6至18岁的青年进行病史采集、人体测量及口服葡萄糖耐量试验。我们根据年龄和性别，将体重指数（BMI）处于第85百分位数或更高定义为“超重”，BMI处于第95百分位数或更高定义为“肥胖”。我们采用国际糖尿病联盟的代谢综合征标准。

结果

在224名符合条件的青年中，192名（85%）参与了研究。19%的青年超重，26%的青年肥胖，36%的青年有中心性肥胖（腰围≥年龄和性别的第90百分位数）。未发现新的T2D病例。空腹血糖受损（IFG 5.6 - 6.9 mmol/L）和葡萄糖耐量受损（IGT 2小时血糖7.8 - 11.0 mmol/L）的患病率分别为19.3%和5.2%。10名IGT青年中有5名空腹血糖低于5.6 mmol/L。代谢综合征的患病率为4.7%，应用儿童高血压标准时升至8.3%。