动力蛋白在出芽酵母中的功能：极化细胞中的有丝分裂纺锤体定位
Function of dynein in budding yeast: mitotic spindle positioning in a polarized cell.
作者信息
Moore Jeffrey K, Stuchell-Brereton Melissa D, Cooper John A
机构信息
Department of Cell Biology and Physiology, Washington University, St Louis, Missouri, USA.
出版信息
Cell Motil Cytoskeleton. 2009 Aug;66(8):546-55. doi: 10.1002/cm.20364.
Abstract
Cytoplasmic dynein is a microtubule motor that powers minus-end-directed motility in a variety of biological settings. The budding yeast, Saccharomyces cerevisiae, has been a useful system for the study of dynein, due to its molecular genetics and cell biology capabilities, coupled with the conservation of dynein-pathway proteins. In this review we discuss how budding yeast use dynein to manipulate the position of the mitotic spindle and the nucleus during cell division, using cytoplasmic microtubules, and we describe our current understanding of the genes required for dynein function. Cell Motil. Cytoskeleton 2009. (c) 2009 Wiley-Liss, Inc.
摘要
胞质动力蛋白是一种微管马达蛋白，在多种生物学环境中驱动向微管负端的运动。由于其分子遗传学和细胞生物学能力，以及动力蛋白信号通路蛋白的保守性，芽殖酵母（酿酒酵母）已成为研究动力蛋白的有用系统。在本综述中，我们讨论了芽殖酵母如何利用胞质微管，在细胞分裂过程中利用动力蛋白来操纵有丝分裂纺锤体和细胞核的位置，并描述了我们目前对动力蛋白功能所需基因的理解。《细胞运动与细胞骨架》2009年。（c）2009威利 - 利斯出版公司。
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