Nguyen Xuan-Mai T, Lane John, Smith Brian R, Nguyen Ninh T
Department of Surgery, University of California, Irvine Medical Center, Orange, CA, USA.
J Gastrointest Surg. 2009 Jul;13(7):1205-12. doi: 10.1007/s11605-009-0904-9. Epub 2009 May 5.
Obesity has been linked with a chronic state of inflammation which may be involved in the development of metabolic syndrome, cardiovascular disease, non-alcoholic steatohepatitis, and even cancer. The objective of this study was to examine the association between obesity class and levels of inflammatory biomarkers from men and women who participated in the 1999-2004 National Health and Nutrition Examination Survey (NHANES).
Serum concentrations of C-reactive protein (CRP) and fibrinogen were measured among US participants of the 1999-2004 NHANES. We examined biomarker levels across different weight classes with normal weight, overweight, and obesity classes 1, 2, and 3 were defined as BMI of < 25.0, 25.0-29.9, 30.0-34.9, 35.0-39.9, and > or = 40.0, respectively.
With CRP levels for normal weight individuals as a reference, CRP levels nearly doubled with each increase in weight class: +0.11 mg/dl (95% CI, 0.06-0.16) for overweight, +0.21 mg/dl (95% CI, 0.16-0.27) for obesity class 1, +0.43 mg/dl (95% CI, 0.26-0.61) for obesity class 2, and +0.73 mg/dl (95% CI, 0.55-0.90) for obesity class 3. With normal weight individuals as a reference, fibrinogen levels increase with increasing weight class and were highest for obesity class 3 individuals, +93.5 mg/dl (95% CI, 72.9-114.1). Individuals with hypertension or diabetes have higher levels of CRP and fibrinogen levels compared to individuals without hypertension or diabetes, even when stratified according to BMI.
There is a direct association between increasing obesity class and the presence of obesity-related comorbidities such as diabetes and hypertension with high levels of inflammatory biomarkers.
肥胖与慢性炎症状态有关，这种炎症状态可能参与代谢综合征、心血管疾病、非酒精性脂肪性肝炎甚至癌症的发生发展。本研究的目的是调查参加1999 - 2004年国家健康与营养检查调查（NHANES）的男性和女性的肥胖类别与炎症生物标志物水平之间的关联。
在1999 - 2004年NHANES的美国参与者中测量血清C反应蛋白（CRP）和纤维蛋白原浓度。我们检查了不同体重类别的生物标志物水平，正常体重、超重以及肥胖1、2和3级的定义分别为体重指数（BMI）<25.0、25.0 - 29.9、30.0 - 34.9、35.0 - 39.9和≥40.0。
以正常体重个体的CRP水平为参照，随着体重类别每增加一级，CRP水平几乎翻倍：超重者增加0.11mg/dl（95%可信区间，0.06 - 0.16），肥胖1级增加0.21mg/dl（95%可信区间，0.16 - 0.27），肥胖2级增加0.43mg/dl（95%可信区间，0.26 - 0.61），肥胖3级增加0.73mg/dl（95%可信区间，0.55 - 0.90）。以正常体重个体为参照，纤维蛋白原水平随着体重类别增加而升高，肥胖3级个体的纤维蛋白原水平最高，增加93.5mg/dl（95%可信区间，72.9 - 114.1）。与无高血压或糖尿病的个体相比，患有高血压或糖尿病的个体CRP和纤维蛋白原水平更高，即使根据BMI进行分层也是如此。
肥胖类别增加与肥胖相关合并症（如糖尿病和高血压）以及高水平炎症生物标志物之间存在直接关联。
