感染肠道贾第鞭毛虫患者体内的γ干扰素、白细胞介素-5、白细胞介素-6和免疫球蛋白E

IFN-gamma, IL-5, IL-6 and IgE in patients infected with Giardia intestinalis.

作者信息

Matowicka-Karna Joanna, Dymicka-Piekarska Violetta, Kemona Halina

机构信息

Department of Clinical Laboratory Diagnostics, Medical University of Białystok, Białystok, Poland.

出版信息

Folia Histochem Cytobiol. 2009;47(1):93-7. doi: 10.2478/v10042-009-0013-3.

DOI:10.2478/v10042-009-0013-3

PMID:19419945

Abstract

The immune system, its cellular and humoral response, is engaged by the host organism to fight against parasitic infections. The study group consisted of 90 patients (58 women and 32 men), aged 18-72 years, infected with G. intestinalis. The diagnosis was established based on laboratory investigations (stool examination, choloscopy, GSA-65). Blood for analysis was collected before (G1), and 2 weeks (G2) and 2 months (G3) after antiparasitic treatment. Control group consisted of 40 healthy subjects (22 women and 18 men), aged 20-45 years. The concentrations of IgE were assayed using a set of VIDAS (bioMerieux) and the concentrations of IL-5, IL-6, IFN-gamma were determined using a set of Quantikine human (R&D Systems). It was revealed that in giardiosis the concentrations of IgE and IL-5 in blood serum were twice as high, the concentration of IL-6 was two and a half times higher and the concentration of IFN-gamma was almost four times higher as compared to healthy controls.

摘要

宿主机体的免疫系统及其细胞和体液反应会参与对抗寄生虫感染。研究组由90名年龄在18至72岁之间、感染了肠贾第虫的患者组成（58名女性和32名男性）。诊断基于实验室检查（粪便检查、胆汁镜检查、GSA - 65）确定。在抗寄生虫治疗前（G1）、治疗后2周（G2）和2个月（G3）采集血样进行分析。对照组由40名年龄在20至45岁之间的健康受试者组成（22名女性和18名男性）。使用一组VIDAS（生物梅里埃公司）检测IgE浓度，使用一组Quantikine human（R&D Systems公司）测定IL - 5、IL - 6、IFN - γ的浓度。结果显示，与健康对照组相比，贾第虫病患者血清中IgE和IL - 5的浓度高出两倍，IL - 6的浓度高出两倍半，IFN - γ的浓度几乎高出四倍。