楝叶吴茱萸素A - C，来自毛叶楝叶吴茱萸的具有前所未有的骨架的16 - 降楝苦素类柠檬苦素。

Chukvelutins A-C, 16-norphragmalin limonoids with unprecedented skeletons from Chukrasia tabularis var. velutina.

作者信息

Luo Jun, Wang Jun-Song, Luo Jian-Guang, Wang Xiao-Bing, Kong Ling-Yi

机构信息

Department of Natural Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.

出版信息

Org Lett. 2009 Jun 4;11(11):2281-4. doi: 10.1021/ol900589h.

DOI:10.1021/ol900589h

PMID:19425541

Abstract

Three new 16-norphragmalin limonoids, chukvelutins A-C (1-3), were isolated from the stem bark of Chukrasia tabularis var. velutina, which possess unprecedented skeletons, featured with a characteristic ketal moiety between the phragmalin skeleton and a biosynthetically extended isobutyryl group at C-15. Their structures were elucidated by extensive spectroscopic technologies.

摘要

从毛红椿（Chukrasia tabularis var. velutina）的茎皮中分离出三种新的16-降苦木素类柠檬苦素，即红椿素A-C（1-3），它们具有前所未有的骨架，其特征是在苦木素骨架和C-15位生物合成延伸的异丁酰基之间有一个独特的缩酮部分。通过广泛的光谱技术阐明了它们的结构。