滑膜活检是否有助于支持关于固有免疫参与白塞病免疫病理学的证据？
Do synovial biopsies help to support evidence for involvement of innate immunity in the immunopathology of Behçet's disease?
作者信息
van Laar Jan A M, Kappen Jasper H, van Daele Paul L A, van Hagen P Martin
出版信息
Arthritis Res Ther. 2009;11(2):109. doi: 10.1186/ar2657. Epub 2009 Apr 30.
Abstract
Behçet's disease is a complex vasculitis of unknown etiology. Abundant neutrophils suggest the involvement of innate immunity. Cytokines are skewed to the T-helper-1 pattern. Few sterile organs are easily accessible for analysis in Behçet's disease. Cañete and coworkers identify inflamed joints as a feasible model and suggest the involvement of innate immunity in Behçet's disease.
摘要
白塞病是一种病因不明的复杂血管炎。大量中性粒细胞提示固有免疫参与其中。细胞因子倾向于T辅助细胞1型模式。在白塞病中，很少有无菌器官便于进行分析。卡涅特及其同事将发炎的关节确定为一个可行的模型，并提示固有免疫参与了白塞病的发病过程。
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