McAnulty Gloria B, Duffy Frank H, Butler Samantha C, Bernstein Jane H, Zurakowski David, Als Heidelise
Departments of Psychiatry, Harvard Medical School and Children's Hospital Boston, 320 Longwood Avenue, Boston, MA 02115, USA.
Clin Pediatr (Phila). 2010 Mar;49(3):258-70. doi: 10.1177/0009922809335668. Epub 2009 May 15.
The current study reports the effects of NIDCAP (Newborn Individualized Developmental Care and Assessment Program) at 8 years of age for a randomized controlled trial of 38 very early born (< or =29 weeks postmenstrual age), high-risk preterm infants. It was hypothesized that the experimental group at school age in comparison with the control group would perform significantly better neuropsychologically and neuroelectrophysiologically. Twenty-two (11 control, 11 experimental) children of the original 38 (18 control, 20 experimental) participants were studied at school age with a detailed neuropsychological battery and with EEG spectral coherence measures. Results indicated significantly better right hemisphere and frontal lobe function in the experimental group than the control group, both neuropsychologically and neurophysiologically. Neurobehavioral and physiological results in the newborn period successfully predicted the beneficial brain function effects at age 8 years. Results support the conclusion that the NIDCAP intervention has lasting effects into school age.
本研究报告了针对38名极早早产(孕龄≤29周)高危早产儿的随机对照试验中,新生儿个体化发育护理与评估计划(NIDCAP)在8岁时的效果。研究假设,与对照组相比,学龄期的实验组在神经心理学和神经电生理学方面的表现会显著更好。在学龄期,对最初38名参与者(18名对照组,20名实验组)中的22名儿童(11名对照组,11名实验组)进行了详细的神经心理测试和脑电图频谱相干性测量。结果表明,无论是在神经心理学还是神经生理学方面,实验组的右半球和额叶功能均显著优于对照组。新生儿期的神经行为和生理结果成功预测了8岁时有益的脑功能效应。结果支持以下结论:NIDCAP干预对学龄期有持久影响。