儿童失神发作
Absence seizures in children.
作者信息
Posner Ewa
机构信息
University Hospital of North Durham, Durham, UK.
出版信息
BMJ Clin Evid. 2008 Jan 10;2008:0317.
INTRODUCTION
About 10% of seizures in children with epilepsy are typical absence seizures. Absence seizures have a significant impact on quality of life.
METHODS AND OUTCOMES
We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments for typical absence seizures in children? We searched: Medline, Embase, The Cochrane Library and other important databases up to October 2007 (BMJ Clinical evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
RESULTS
We found 16 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
CONCLUSIONS
In this systematic review we present information relating to the effectiveness and safety of the following interventions: clonazepam, ethosuximide, gabapentin, lamotrigine, and valproate.
引言
癫痫患儿中约10%的发作类型为典型失神发作。失神发作对生活质量有重大影响。
方法与结果
我们进行了一项系统评价，旨在回答以下临床问题：儿童典型失神发作的治疗效果如何？我们检索了：截至2007年10月的医学期刊数据库（Medline）、荷兰医学文摘数据库（Embase）、考克兰图书馆及其他重要数据库（《英国医学杂志》临床证据综述会定期更新，请查阅我们的网站获取本综述的最新版本）。我们纳入了来自美国食品药品监督管理局（FDA）和英国药品及医疗保健产品监管局（MHRA）等相关组织的危害警示。
结果
我们找到了16项符合我们纳入标准的系统评价、随机对照试验或观察性研究。我们对干预措施的证据质量进行了GRADE评估。
结论
在本系统评价中，我们提供了有关以下干预措施有效性和安全性的信息：氯硝西泮、乙琥胺、加巴喷丁、拉莫三嗪和丙戊酸盐。
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