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以色列多杀巴斯德菌感染的六年全国性回顾性调查。

A retrospective six-year national survey of P. multocida infections in Israel.

作者信息

Nseir William, Giladi M, Moroz I, Moses A E, Benenson S, Finkelstein R, Dan M, Chazan B, Bishara J, Ben-Dror G, Hassin D, Peled N, Rahav G, Grupper M, Potasman I

机构信息

Holy Family Hospital, Nazareth, Israel.

出版信息

Scand J Infect Dis. 2009;41(6-7):445-9. doi: 10.1080/00365540902968035.

Abstract

Pasteurella multocida is the commonest organism infecting pet bites. Anecdotal reports tend to overemphasize dramatic outcomes. We aimed to study a large database of P. multocida infections. This retrospective survey of P. multocida infections in Israeli hospitals refers to the y 2000-2005. Clinical microbiologists were contacted by email and asked to perform a back-search of their hospital's records for isolates of P. multocida. The charts of patients growing P. multocida were abstracted into a structured questionnaire. 77 cases were identified in 12 hospitals, yielding an annual incidence of 0.19/100,000. The mean age was 49.2+/-26.5 y and the mortality rate was 2.6%. Those who died were >65 y of age, had diabetes mellitus or cirrhosis and were bacteraemic. One-third of the cases occurred in people aged > or =65 y. Cats caused most of these infections (54%). Surgery for debridement was common (53.7%), but no-one required amputation; a second- and third-look operation was necessary for these patients. Bacteraemia was found in 32.5% of patients and was significantly more common among those aged >60 y (p =0.044). Hospitalized patients with P. multocida have a favourable prognosis, apart from elderly and bacteraemic patients with comorbidities. Surgery and reoperations may be required in about half of the patients.

摘要

多杀巴斯德菌是感染宠物咬伤最常见的病原体。轶事报道往往过度强调严重后果。我们旨在研究一个关于多杀巴斯德菌感染的大型数据库。这项对以色列医院多杀巴斯德菌感染的回顾性调查涵盖了2000 - 2005年。通过电子邮件联系临床微生物学家,要求他们对所在医院记录中多杀巴斯德菌的分离株进行回溯性检索。培养出多杀巴斯德菌的患者病历被录入一份结构化问卷。在12家医院共识别出77例病例,年发病率为0.19/10万。平均年龄为49.2±26.5岁,死亡率为2.6%。死亡患者年龄大于65岁,患有糖尿病或肝硬化且发生了菌血症。三分之一的病例发生在年龄大于或等于65岁的人群中。猫导致了这些感染中的大多数(54%)。清创手术很常见(53.7%),但无人需要截肢;这些患者需要进行二次和三次探查手术。32.5%的患者出现菌血症,在年龄大于60岁的患者中显著更常见(p = 0.044)。除了患有合并症的老年菌血症患者外,住院的多杀巴斯德菌感染患者预后良好。约一半的患者可能需要手术和再次手术。

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