介入心脏病学转化研究中的临床前动物模型。
The pre-clinical animal model in the translational research of interventional cardiology.
机构信息
Division of Cardiovascular Medicine, School of Medicine, Stanford University, Stanford, California 94305, USA.
出版信息
JACC Cardiovasc Interv. 2009 May;2(5):373-83. doi: 10.1016/j.jcin.2009.03.004.
Scientific discoveries for improvement of human health must be translated into practical applications. Such discoveries typically begin at "the bench" with basic research, then progress to the clinical level. In particular, in the field of interventional cardiology, percutaneous cardiovascular intervention has rapidly evolved from an experimental procedure to a therapeutic clinical setting. Pre-clinical studies using animal models play a very important role in the evaluation of efficacy and safety of new medical devices before their use in human clinical studies. This review provides an overview of the emerging role, results of pre-clinical studies and development, and evaluation of animal models for percutaneous cardiovascular intervention technologies for patients with symptomatic cardiovascular disease.
为改善人类健康而进行的科学发现必须转化为实际应用。这些发现通常从基础研究的“实验室”开始，然后逐步发展到临床水平。特别是在介入心脏病学领域，经皮心血管介入已经从一种实验性操作迅速发展成为一种治疗性的临床设置。在新医疗器械用于人体临床研究之前，使用动物模型进行的临床前研究对于评估其疗效和安全性非常重要。本文综述了用于治疗有症状心血管疾病患者的经皮心血管介入技术的动物模型在新兴作用、临床前研究结果和发展以及评估方面的作用。
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