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活跃产程和分娩方式对极低出生体重儿来说仍是挑战吗?一家三级护理医院的经验。

Are active labour and mode of delivery still a challenge for extremely low birth weight infants? Experience at a tertiary care hospital.

作者信息

Vimercati Antonella, Scioscia Marco, Nardelli Claudia, Panella Emma, Laforgia Nicola, Decosmo Lucrezia, Selvaggi Luigi E

机构信息

Department of Gynaecology, Obstetrics and Neonatology, University of Medical Science of Bari, Bari, Italy.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2009 Aug;145(2):154-7. doi: 10.1016/j.ejogrb.2009.04.026. Epub 2009 May 22.

Abstract

OBJECTIVE

This study was to evaluate the impact of mode of delivery and timing of caesarean section in extremely preterm births, below 28 weeks of gestation, on long-term survival and psychomotor outcomes.

STUDY DESIGN

This was a single-centre retrospective cohort study of 84 cases of extremely low birth weight infants with complete maternal, obstetrical and neonatological information. Mortality and survival with neurological disabilities at 18 months of life were considered outcome measures.

RESULTS

Forty percent of deliveries were at or less than 25 weeks of gestation and birth weight was <or=500 g in 14% of all infants. The overall survival rate was 54.8% with a prevalence of neuromotor impairment with disability among the survivors of 26.1%. After adjustment using multiple logistic regression, only extreme prematurity (<or=25 weeks) and birth weight below 500 g had significant effects on survival (p<0.05), regardless of mode and timing of delivery.

CONCLUSIONS

Mode of delivery and labour seem not to play a significant role in adverse neonatal outcomes, either mortality or neuro-developmental impairment, in extremely low birth weight infants.

摘要

目的

本研究旨在评估分娩方式和剖宫产时机对妊娠28周以下极早早产儿长期生存及精神运动发育结局的影响。

研究设计

这是一项单中心回顾性队列研究,纳入84例极低出生体重儿,收集了完整的母亲、产科和新生儿科信息。以18个月时的死亡率和伴有神经功能障碍的生存率作为结局指标。

结果

40%的分娩发生在妊娠25周及以内,所有婴儿中14%的出生体重≤500g。总体生存率为54.8%,幸存者中神经运动功能障碍伴残疾的患病率为26.1%。经多因素logistic回归调整后,无论分娩方式和时机如何,仅极早早产(≤25周)和出生体重低于500g对生存有显著影响(p<0.05)。

结论

分娩方式和产程似乎对极低出生体重儿的不良新生儿结局(无论是死亡率还是神经发育障碍)不起重要作用。

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