School of Medical Sciences, Universiti Sains Malaysia Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia.
J Clin Immunol. 2009 Sep;29(5):595-602. doi: 10.1007/s10875-009-9300-1. Epub 2009 May 27.
The peroxisome proliferator-activated receptors (PPARs) have been implicated in immune regulation. We determined the transcriptional expression of the three isoforms, PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages, CD4- and CD8-positive lymphocytes in non-obese diabetic (NOD) mice at 5 and 10 weeks of age as well as at diabetic stage.
Compared to the non-obese diabetic resistant (NOR) mice, the peritoneal macrophages of NOD mice expressed increased levels of PPARalpha but reduced levels of PPARgamma2, while PPARgamma1 expression was unchanged in all age groups. CD4-positive lymphocytes expressed low levels of PPARalpha in diabetic NOD mice and greatly reduced expression of PPARgamma2 in all age groups. Unlike peritoneal macrophages and CD4-positive cells, the CD8-positive cells expressed low levels of PPARgamma1 in diabetic NOD mice but no difference in PPARalpha and PPARgamma2 expression was observed compared to NOR mice.
The current findings may suggest an important regulatory role of PPARs in the pathogenesis of autoimmune diabetes.
过氧化物酶体增殖物激活受体（PPARs）已被牵涉到免疫调节中。我们测定了非肥胖型糖尿病（NOD）小鼠在 5 周和 10 周龄以及糖尿病期时腹膜巨噬细胞、CD4阳性和 CD8阳性淋巴细胞中三种亚型（PPARalpha、PPARgamma1 和 PPARgamma2）的转录表达。
与非肥胖型糖尿病抗性（NOR）小鼠相比，NOD 小鼠的腹膜巨噬细胞表达了更高水平的 PPARalpha，但 PPARgamma2 的水平降低，而所有年龄组的 PPARgamma1 表达均无变化。糖尿病 NOD 小鼠的 CD4阳性淋巴细胞表达低水平的 PPARalpha，而所有年龄组的 PPARgamma2 表达均大大降低。与腹膜巨噬细胞和 CD4阳性细胞不同，CD8阳性细胞在糖尿病 NOD 小鼠中表达低水平的 PPARgamma1，但与 NOR 小鼠相比，PPARalpha 和 PPARgamma2 的表达无差异。
目前的研究结果可能提示 PPARs 在自身免疫性糖尿病发病机制中具有重要的调节作用。
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