中国老年人群中的代谢综合征与认知障碍：一项横断面研究。

Metabolic syndrome and cognitive impairment amongst elderly people in Chinese population: a cross-sectional study.

作者信息

Liu C-Y, Zhou H-D, Xu Z-Q, Zhang W-W, Li X-Y, Zhao J

机构信息

Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, China.

出版信息

Eur J Neurol. 2009 Sep;16(9):1022-7. doi: 10.1111/j.1468-1331.2009.02640.x. Epub 2009 Apr 16.

DOI:10.1111/j.1468-1331.2009.02640.x

PMID:19473351

Abstract

BACKGROUND AND PURPOSE

Recent studies have demonstrated an association between metabolic syndrome (MetS) and cognitive impairment in elderly individuals, however a relationship between MetS and cognitive impairment in the Chinese population has been less frequently reported. Therefore, the present study was designed to investigate the relationship between MetS and cognitive impairment in an elderly Chinese population.

METHODS

Of 3216 participants (1740 men and 1476 women), aged 60 years old and over were selected from three districts of Chongqing City. The presence of MetS was defined according to the updated Adult Treatment Panel III criteria, and cognitive function was measured by Mini-Mental State Examination and the Activity of Daily Living tests.

RESULTS

Of the 3216 participants, 733 (22.8%) fulfilled the criteria for MetS, and 470 participants (14.6%; 236 men and 234 women) fulfilled the criteria for cognitive impairment. Amongst those with MetS, 183 participants (25%) also had cognitive impairment. In univariate analysis, MetS was significantly associated with cognitive impairment [odds ratio (OR) 2.55; 95% confidence interval (CI) 2.07-3.13]. Taking age, current smoking, hypertension and diabetes into account, multivariate logistic regression analysis showed that MetS was significantly associated with cognitive impairment (OR 2.31; 95% CI 1.91-2.95).

CONCLUSION

MetS is associated with cognitive impairment amongst elderly people in the Chinese population.

摘要

背景与目的

近期研究表明，老年人群中代谢综合征（MetS）与认知障碍之间存在关联，然而，中国人群中MetS与认知障碍之间的关系鲜见报道。因此，本研究旨在调查中国老年人群中MetS与认知障碍之间的关系。

方法

从重庆市三个区选取3216名年龄在60岁及以上的参与者（1740名男性和1476名女性）。根据更新后的成人治疗小组III标准定义MetS的存在，并通过简易精神状态检查表和日常生活活动测试来测量认知功能。

结果

在3216名参与者中，733名（22.8%）符合MetS标准，470名参与者（14.6%；236名男性和234名女性）符合认知障碍标准。在患有MetS的人群中，183名参与者（25%）也存在认知障碍。在单因素分析中，MetS与认知障碍显著相关[比值比（OR）2.55；95%置信区间（CI）2.07 - 3.13]。在考虑年龄、当前吸烟状况、高血压和糖尿病因素后，多因素逻辑回归分析显示，MetS与认知障碍显著相关（OR 2.31；95% CI 1.91 - 2.95）。