The Hebrew-University Hadassah Medical School, Department of Obstetrics and Gynecology, Jerusalem, Israel.
Climacteric. 2009 Oct;12(5):404-9. doi: 10.1080/13697130902780846.
The most effective strategy for prevention of ovarian and breast cancer in high-risk women is bilateral salpingo-oophorectomy. The inevitable consequence of the procedure is early menopause with the associated climacteric symptoms. Little is known about the nature of the symptoms in women who undergo risk-reducing bilateral salpingo-oophorectomy.
To compare the nature, frequency, severity, duration, and overall effects of climacteric symptoms in a group of women who underwent preventive bilateral salpingo-oophorectomy as compared to women who experienced natural menopause.
Forty-eight women at high risk for ovarian cancer who had risk-reducing bilateral salpingo-oophorectomy were compared to 60 postmenopausal women who had natural menopause. The participants were interviewed about their climacteric complaints, thoughts and feelings regarding the surgical procedure and their general well-being. The climacteric symptoms were evaluated by a modified Greene Climacteric Scale.
Surgical menopause, as compared to natural menopause, was associated with more severe psychological, vasomotor and somatic climacteric symptoms (total score 17.36 vs. 8.65, respectively, p < 0.001) and more significant sexual dysfunction (1.848 vs. 0.900, respectively, p < 0.01). On a 0-10 scale, the satisfaction rate from the surgical procedure was 8.23 +/- 2.21. The surgery did not affect the perceived quality of life (p = 0.347) and decreased the score of anxiety and cancer fear (from 7.75 +/- 3.31 preoperatively to 2.94 +/- 3.08 postoperatively, p < 0.001).
Risk-reducing bilateral salpingo-oophorectomy as compared to natural menopause is associated with more severe climacteric symptoms. However, the procedure does not interfere with the overall perceived quality of life and improves the perception of cancer risk.
预防高危女性卵巢癌和乳腺癌的最有效策略是双侧输卵管卵巢切除术。该手术不可避免的后果是提前绝经，随之出现更年期症状。对于接受预防性双侧输卵管卵巢切除术的女性，其更年期症状的性质尚不清楚。
比较一组接受预防性双侧输卵管卵巢切除术的女性与自然绝经的女性的更年期症状的性质、频率、严重程度、持续时间和总体影响。
将 48 名患有卵巢癌高危风险的女性（接受预防性双侧输卵管卵巢切除术）与 60 名自然绝经的女性（接受自然绝经）进行比较。通过改良格林绝经量表对患者的更年期症状、对手术过程的想法和感受以及整体健康状况进行评估。
与自然绝经相比，手术性绝经与更严重的心理、血管舒缩和躯体更年期症状（总评分分别为 17.36 分和 8.65 分，p < 0.001）和更显著的性功能障碍（分别为 1.848 分和 0.900 分，p < 0.01）相关。手术的满意度评分为 8.23 ± 2.21。手术并未影响生活质量（p = 0.347），且降低了焦虑和癌症恐惧评分（从术前的 7.75 ± 3.31 降至术后的 2.94 ± 3.08，p < 0.001）。
与自然绝经相比，预防性双侧输卵管卵巢切除术与更严重的更年期症状相关。然而，该手术不会影响整体生活质量，且可降低对癌症风险的感知。
