[双能X线吸收法检测外源性脂肪对骨密度的影响]
[Effect of exogenous fat on bone mineral density by DXA].
作者信息
Wu Yuan, Deng Xiaoge
机构信息
Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 May;34(5):439-42.
OBJECTIVE
To observe the effect of exogenous fat on the bone mineral density (BMD) of lumbar spine (LS) on a phantom measured by dual energy X-ray absorptiometry (DXA) Hologic QDR4500A.
METHODS
LS DXA scans were performed on an LS phantom, and were repeated when with lard packets (2 fresh lard packets and 2 refined lard packets, 5 cm or 10 cm thick).
RESULTS
After fresh lard packets were placed, only L1 BMD decreased significantly (P<0.05).When the 5 cm-thick refined lard packet was placed, BMD, bone mineral content (BMC),and bone area (BA) decreased obviously, but with the 10 cm-thick refined lard packet, BMD, BMC and BA decreased significantly (P<0.05 or P<0.01).
CONCLUSION
The exogenous fat may affect LS BMD of lumbar spine phantom by DXA Hologic QDR4500A, with significant decrease of the value,which may cause anomaly measurement of BMD in obese people and even misdiagnosis of osteoporosis.
目的
观察外源性脂肪对通过双能X线吸收法（DXA）Hologic QDR4500A测量的腰椎（LS）模型骨密度（BMD）的影响。
方法
对腰椎模型进行腰椎DXA扫描，在放置猪油包（2个新鲜猪油包和2个精炼猪油包，厚度为5厘米或10厘米）时重复扫描。
结果
放置新鲜猪油包后，仅L1的骨密度显著降低（P<0.05）。当放置5厘米厚的精炼猪油包时，骨密度、骨矿物质含量（BMC）和骨面积（BA）明显降低，但放置10厘米厚的精炼猪油包时，骨密度、BMC和BA显著降低（P<0.05或P<0.01）。
结论
外源性脂肪可能会影响通过DXA Hologic QDR4500A测量的腰椎模型的腰椎骨密度，其值显著降低，这可能导致肥胖人群骨密度测量异常，甚至骨质疏松的误诊。
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