宫内超声测量胚胎脑幔。

Department of Perinatology and Gynecology, Kagawa University School of Medicine, Miki, Kagawa, Japan.

Ultrasound Obstet Gynecol. 2009 Jul;34(1):47-51. doi: 10.1002/uog.6305.

OBJECTIVE

To evaluate embryonic brain mantle measurements using intrauterine sonography in the early first trimester.

METHODS

In 85 women about to undergo therapeutic termination at 6-11 weeks' gestation we studied the embryonic brain mantle using a specially developed 20-MHz, flexible, catheter-based, high-resolution, real-time, miniature (1.8 mm in outer diameter) ultrasound transducer. Thickness of the embryonic brain telencephalon, diencephalon, mesencephalon and rhombencephalon was measured.

RESULTS

We found a linear relationship between gestational age and telencephalon thickness (R(2) = 51.9%, P < 0.0001), diencephalon thickness (R(2) = 62.2%, P < 0.0001), mesencephalon thickness (R(2) = 59.2%, P < 0.0001) and rhombencephalon thickness (R(2) = 47.8%, P = 0.0043). There was also a linear relationship between crown-rump length and telencephalon thickness (R(2) = 55.0%, P < 0.0001), diencephalon thickness (R(2) = 59.6%, P < 0.0001), mesencephalon thickness (R(2) = 55.0%, P < 0.0001) and rhombencephalon thickness (R(2) = 52.3%, P = 0.0025).

CONCLUSIONS

Embryonic brain mantle measurements by intrauterine sonography are feasible, although the invasive nature of this technique limits its usefulness in routine clinical practice. It is possible, however, that further improvement in the resolution of transvaginal sonography will allow accurate and reproducible non-invasive imaging of embryonic brain mantle development in the near future.

目的

评估孕早期经阴道超声检测胚胎脑幕的测量值。

方法

对 85 例 6-11 周因治疗需要行人工流产术的孕妇，应用特制的 20MHz 、可弯曲、导管式、高分辨率、实时、微型（外径 1.8mm）超声探头检测胚胎脑幕。测量胚胎端脑、间脑、中脑和后脑的厚度。

结果

我们发现脑端脑厚度（R²=51.9%，P<0.0001）、间脑厚度（R²=62.2%，P<0.0001）、中脑厚度（R²=59.2%，P<0.0001）和后脑厚度（R²=47.8%，P=0.0043）与孕龄均呈线性相关。头臀长与脑端脑厚度（R²=55.0%，P<0.0001）、间脑厚度（R²=59.6%，P<0.0001）、中脑厚度（R²=55.0%，P<0.0001）和后脑厚度（R²=52.3%，P=0.0025）也呈线性相关。