Lanzavecchia Antonio, Sallusto Federica
Institute for Research in Biomedicine, Bellinzona, Switzerland.
Curr Opin Immunol. 2009 Jun;21(3):298-304. doi: 10.1016/j.coi.2009.05.019. Epub 2009 Jun 6.
Following an immune response two types of differentiated B cells persist in the memory pool: plasma cells, which confer immediate protection by the secretion of specific antibodies; and memory B cells, which confer rapid and enhanced response to secondary challenge. We will review recent advances in understanding the heterogeneity, dynamics, and persistence of human memory B cells and plasma cells as well as new methods to isolate human monoclonal antibodies. These findings offer new insights into the human B cell response, which are relevant for vaccination and therapeutic intervention.
免疫反应后,两种分化的B细胞会持续存在于记忆库中:浆细胞,通过分泌特异性抗体提供即时保护;记忆B细胞,对二次刺激产生快速且增强的反应。我们将综述在理解人类记忆B细胞和浆细胞的异质性、动态变化及持久性方面的最新进展,以及分离人类单克隆抗体的新方法。这些发现为人类B细胞反应提供了新的见解,这与疫苗接种和治疗干预相关。