St John Paul A
Department of Cell Biology and Anatomy, University of Arizona College of Medicine, Tucson, AZ 85724, USA.
Acta Pharmacol Sin. 2009 Jun;30(6):656-62. doi: 10.1038/aps.2009.76.
Nicotinic acetylcholine receptors (nAChRs) play critical roles throughout the body. Precise regulation of the cellular location and availability of nAChRs on neurons and target cells is critical to their proper function. Dynamic, post-translational regulation of nAChRs, particularly control of their movements among the different compartments of cells, is an important aspect of that regulation. A combination of new information and new techniques has the study of nAChR trafficking poised for new breakthroughs.
烟碱型乙酰胆碱受体(nAChRs)在全身发挥着关键作用。精确调节神经元和靶细胞上nAChRs的细胞定位和可用性对其正常功能至关重要。nAChRs的动态翻译后调节,尤其是对其在细胞不同区室间移动的控制,是该调节的一个重要方面。新信息与新技术的结合使nAChR转运的研究有望取得新突破。