Iampol'skaia S A
Arkh Patol. 2009 Mar-Apr;71(2):47-51.
The specific features of the pathological histology of scleroma have been continuously studied at the Pathology Department of the Lvov Medical University since 1945. A total of 1025 biopsy specimens from 656 patients with scleroma were examined. Along with diverse dystrophic and metaplastic changes in the epithelial coverings, which were affected by scleroma, there were its original inflammatory enlargements that were likely to play an active part in the inflammatory process. Abundant formation of fibrous structures in the granulation tissue undoubtedly reflects the protective functioning of an organism. Impaired innervation led not only to ageusia and anosmia in patients with scleroma; loss of nervous communications with the organism is very likely to affect the course of the pathological process to either degree. Electron microscopy provided more evidence for the presence of endobiosis in scleroma and the inability of drugs to affect directly the Frish bacillus due to its secreted mucopolysaccharide the composition of which is little studied.
自1945年以来，利沃夫医科大学病理科一直在持续研究硬结病的病理组织学特征。共检查了656例硬结病患者的1025份活检标本。除了硬结病所累及的上皮覆盖物出现各种营养不良性和化生改变外，还有其特有的炎症性肿大，这些肿大可能在炎症过程中发挥积极作用。肉芽组织中大量纤维结构的形成无疑反映了机体的保护功能。神经支配受损不仅导致硬结病患者味觉丧失和嗅觉丧失；与机体神经联系的丧失很可能在一定程度上影响病理过程的发展。电子显微镜为硬结病内共生现象的存在以及药物由于弗氏杆菌分泌的粘多糖（其成分研究较少）而无法直接影响该杆菌提供了更多证据。
