Miranda Marco A, Radhakrishnan Hema, O'donnell Clare
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
Cornea. 2009 Jul;28(6):657-66. doi: 10.1097/ICO.0b013e31819b01b5.
To estimate the variability of Scheimpflug imaging measurements over a 1-week period and to determine the impact of age on the measurements and on the variability of the parameters in the study.
Three consecutive measurements of anterior and posterior corneal P values (CPVs), central corneal radii (horizontal and vertical), and sagittal corneal radii (at the apex and along an 8-mm diameter ring) were performed on one eye of 23 healthy subjects. Measurements were obtained at 3 different sessions with intervals of a few seconds, 1 hour, and 1 week, under scotopic conditions and immediately after a blink.
In general, no clinically or statistically significant differences were found in within-subjects variance between the three time scales. Confidence limits from Bland and Altman analysis within the first session, and between the first and second sessions, and between the first and third sessions ranged between +/-0.09 and +/-0.18 for anterior and posterior CPV, and between +/-0.03 mm and +/-0.27 mm for anterior and posterior corneal radii (central and sagittal radii). Anterior and posterior corneal measurements and the variability of these measurements were not found to change significantly as a function of age.
The Oculus Pentacam provides repeatable measures of the metrics derived from corneal topography over the tested time scales. In subjects aged from 19 to 40 years, topography measurements and their respective variability did not seem to change significantly with age.
评估在1周时间内Scheimpflug成像测量的变异性,并确定年龄对测量结果以及研究中参数变异性的影响。
对23名健康受试者的一只眼睛进行了连续三次测量,包括角膜前后P值(CPV)、中央角膜半径(水平和垂直)以及矢状角膜半径(在顶点处和沿直径8 mm的环)。在暗视条件下且眨眼后立即进行测量,测量在3个不同时间段进行,间隔分别为几秒、1小时和1周。
总体而言,在三个时间尺度上,受试者内方差未发现临床或统计学上的显著差异。Bland和Altman分析得出的第一次测量期间、第一次和第二次测量之间以及第一次和第三次测量之间的置信限,对于角膜前后CPV在±0.09至±0.18之间,对于角膜前后半径(中央和矢状半径)在±0.03 mm至±0.27 mm之间。未发现角膜前后测量结果及其变异性随年龄有显著变化。
Oculus Pentacam在测试的时间尺度上能提供来自角膜地形图指标的可重复测量。在19至40岁的受试者中,地形图测量结果及其各自的变异性似乎不会随年龄显著变化。