癌症中的RNA干扰：靶向抗凋亡蛋白c-FLIP用于药物研发。
RNA interference in cancer: targeting the anti-apoptotic protein c-FLIP for drug discovery.
作者信息
Day Travis W, Safa Ahmad R
机构信息
Department of Pharmacology and Toxicology, Indiana University Simon Cancer Center, Indianapolis, IN 46202, USA.
出版信息
Mini Rev Med Chem. 2009 Jun;9(6):741-8. doi: 10.2174/138955709788452748.
PMID:19519499
Abstract
The silencing of genes by RNA interference (RNAi) has identified proteins involved in the resistance of cancers to chemotherapeutic drugs. Resistance is associated with defects in the apoptotic signaling pathways. In this article, we examine using RNAi to target the anti-apoptotic protein cellular FLICE-like inhibitory protein (c-FLIP) for drug development.
摘要
通过RNA干扰（RNAi）使基因沉默，已鉴定出参与癌症对化疗药物耐药性的蛋白质。耐药性与凋亡信号通路的缺陷有关。在本文中，我们研究了利用RNAi靶向抗凋亡蛋白细胞FLICE样抑制蛋白（c-FLIP）进行药物开发。
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