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[遗传学与高血压]

[Genetics and hypertension].

作者信息

Ellervik Christina, Tarnow Lise, Pedersen Erling Bjerregaard

机构信息

Medicinsk Forskning og Medicinsk Afdeling, Regionshospitalet Holstebro, DK-7500 Holstebro.

出版信息

Ugeskr Laeger. 2009 Jun 8;171(24):2012-5.

Abstract

Monogenic forms of hypertension are very rare, but have a well-characterized heredity. Primary hypertension is very common with a complex and polygenic heredity. Primary hypertension arises due to an interaction between multiple genetic and environmental factors. Its heredity is unknown, although some candidate genes have been suggested. Intense research is ongoing and includes the use of modern genetics methods as genome wide association and linkage studies.

摘要

单基因形式的高血压非常罕见,但具有明确的遗传特征。原发性高血压非常常见,具有复杂的多基因遗传。原发性高血压是由多种遗传和环境因素相互作用引起的。尽管已经提出了一些候选基因,但其遗传情况尚不清楚。目前正在进行深入研究,包括使用全基因组关联和连锁研究等现代遗传学方法。

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