Cytotoxic thiophenes from the root of Echinops grijisii Hance.

作者信息

Zhang Peng, Liang Dong, Jin Wenrong, Qu Haibin, Cheng Yiyu, Li Xian, Ma Zhongjun

机构信息

Institute of Pharmaceutical Informatics, School of Pharmaceutical Sciences, Zhejiang University, Zijingang Campus, No. 388 Yuhangtang Rd., Hangzhou 310058, China.

出版信息

Z Naturforsch C J Biosci. 2009 Mar-Apr;64(3-4):193-6. doi: 10.1515/znc-2009-3-407.

DOI:10.1515/znc-2009-3-407

PMID:19526711

Abstract

A new thiophene, echinothiophenegenol (1), together with seven known thiophenes was isolated from the crude ethanol extract of roots of Echinops grijisii Hance. The structure of 1 was elucidated on the basis of spectroscopic data. Compounds 2 and 5, isolated from the plant for the first time, and compounds 1-7 were tested for their cytotoxicity against two human cancer cell lines, HL60 and K562. The thiophenes showed better activity than the bithiophenes.

摘要