冷球蛋白检测观察：II. 丙型肝炎病毒感染患者中寡克隆混合冷球蛋白血症与肝硬化的关联
Observations on cryoglobulin testing: II. The association of oligoclonal mixed cryoglobulinemia with cirrhosis in patients infected with hepatitis C virus.
作者信息
De Rosa Francesco G, Abel György, Agnello Vincent
机构信息
Department of Laboratory Medicine, Lahey Clinic, Burlington, MA 01805, USA.
出版信息
J Rheumatol. 2009 Sep;36(9):1956-7. doi: 10.3899/jrheum.090189. Epub 2009 Jun 16.
OBJECTIVE
To determine whether a mixed cryoglobulin type correlated with cirrhosis in patients infected with hepatitis C virus (HCV).
METHODS
We investigated the results of mixed cryoglobulin tests performed in the clinical laboratory on patients with and without HCV infection.
RESULTS
A higher prevalence of oligoclonal cryoglobulins designated Type IIa was present in HCV-infected patients with cirrhosis than in those without cirrhosis.
CONCLUSION
An association of Type IIa cryoglobulins with cirrhosis in HCV-infected patients has not previously been reported.
目的
确定混合性冷球蛋白类型是否与丙型肝炎病毒（HCV）感染患者的肝硬化相关。
方法
我们调查了临床实验室对有或无HCV感染患者进行的混合性冷球蛋白检测结果。
结果
与未患肝硬化的HCV感染患者相比，患肝硬化的HCV感染患者中，指定为IIa型的寡克隆冷球蛋白患病率更高。
结论
此前尚未报道IIa型冷球蛋白与HCV感染患者的肝硬化有关联。
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