波兰特纳综合征女性的激素替代疗法：176 例分析。

Hormonal replacement therapy in women with Turner's syndrome in Poland: Analysis of 176 cases.

机构信息

Out Patient Clinic for Women with Turner Syndrome, the Specialist Hospital No 2, Bytom, Poland.

出版信息

Gynecol Endocrinol. 2009 Aug;25(8):546-50. doi: 10.1080/09513590903015510.

DOI:10.1080/09513590903015510

PMID:19544120

Abstract

AIM

Turner syndrome (TS) is one of the forms of gonadal malfunction. The study aims at the analysis of hypophysis-gonad axis (HGA) of women with TS who use and do not use hormonal replacement therapy (HRT).

METHOD

One hundred and seventy-six Poles with TS were investigated in the years 1995-2004. The information about the application of HRT was given during the interview. The HGA was examined by the estimation of gonadotropin (FSH, LH) and 17beta-estradiol (E(2)) levels.

RESULTS

HRT was administered to 89% of women with TS at some point of their life. However, at the time of writing this report only 54% of them have been taking this drug. The variety of hormonal preparations used by the patients was great. In women with TS using the HRT, in contradiction to women with TS who do not use it, lower concentrations of FSH (32.1 +/- 22.1 vs. 44.2 +/- 23.3 IU/l) and LH (20.8 +/- 17.5 vs. 26.6 +/- 18.1 IU/l) as well as higher level of E(2) (135.5 +/- 147.9 vs. 89.9 +/- 100.6 pmol/l) were observed. The negative correlation between E(2) and FSH levels was not observed in women with TS using HRT, despite the elevation of 17beta-estradiol levels and the reduction of gonadotropin concentration.

CONCLUSIONS

(1) Large percentage of women with TS does not use HRT. (2) Women with TS, who receive HRT, use this method of treatment insufficiently.

摘要

目的

特纳综合征（TS）是性腺功能障碍的一种形式。本研究旨在分析使用和不使用激素替代疗法（HRT）的 TS 女性的垂体-性腺轴（HGA）。

方法

1995 年至 2004 年期间，对 176 名波兰 TS 患者进行了调查。在访谈中提供了关于 HRT 应用的信息。通过估计促性腺激素（FSH、LH）和 17β-雌二醇（E（2））水平来检查 HGA。

结果

TS 患者中有 89%在其生命中的某个阶段使用过 HRT。然而，在撰写本报告时，只有 54%的患者仍在服用该药物。患者使用的激素制剂种类繁多。在使用 HRT 的 TS 女性中，与未使用 HRT 的 TS 女性相比，FSH（32.1 ± 22.1 与 44.2 ± 23.3 IU/l）和 LH（20.8 ± 17.5 与 26.6 ± 18.1 IU/l）浓度较低，E（2）水平较高（135.5 ± 147.9 与 89.9 ± 100.6 pmol/l）。尽管 17β-雌二醇水平升高和促性腺激素浓度降低，但使用 HRT 的 TS 女性中未观察到 E（2）与 FSH 水平之间的负相关。