C反应蛋白：一种用于指导疑似新生儿败血症抗生素治疗疗程的有用标志物？

C-reactive protein: a useful marker for guiding duration of antibiotic therapy in suspected neonatal septicaemia?

作者信息

Al-Zwaini E J

机构信息

Department of Paediatrics, College of Medicine, Al-Kindi Medical College, Baghdad University Baghdad, Iraq.

出版信息

East Mediterr Health J. 2009 Mar-Apr;15(2):269-75.

PMID:19554972

Abstract

The study aimed to determine whether serum C-reactive protein (CRP) levels can be used to identify when antibiotics can safely be discontinued in cases of suspected neonatal septicaemia. Neonates with suspected neonatal septicaemia treated at a hospital in Al Ramadi city, Iraq, in 2005 had serum CRP and blood cultures (the gold standard) done at admission and at 48 hours, 4 days and 6 days after starting treatment. Of the 55 neonates, CRP was < or =6 mg/L at 48 hours in 37 (67.3%) and antibiotics could be stopped in 32 (82.5%), i.e., when blood culture was negative. The moderate sensitivity (78%) and negative predictive value (86%) of serum CRP in this study suggest that this test alone cannot be used for guiding duration of antibiotic treatment for neonatal sepsis.

摘要

该研究旨在确定血清C反应蛋白（CRP）水平是否可用于确定疑似新生儿败血症病例何时能够安全停用抗生素。2005年在伊拉克拉马迪市一家医院接受治疗的疑似新生儿败血症的新生儿，在入院时以及开始治疗后的48小时、4天和6天进行了血清CRP检测和血培养（金标准）。在这55例新生儿中，37例（67.3%）在48小时时CRP≤6mg/L，其中32例（82.5%）在血培养阴性时停用了抗生素。本研究中血清CRP的中度敏感性（78%）和阴性预测值（86%）表明，仅这项检测不能用于指导新生儿败血症抗生素治疗的疗程。