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Endoscopic ulcers are neither meaningful nor validated as a surrogate for clinically significant upper gastrointestinal harm.

作者信息

Graham David Y

出版信息

Clin Gastroenterol Hepatol. 2009 Nov;7(11):1147-50. doi: 10.1016/j.cgh.2009.06.006. Epub 2009 Jun 25.

Abstract
摘要

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本文引用的文献

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Evidence for endoscopic ulcers as meaningful surrogate endpoint for clinically significant upper gastrointestinal harm.
Clin Gastroenterol Hepatol. 2009 Nov;7(11):1156-63. doi: 10.1016/j.cgh.2009.03.032. Epub 2009 Apr 9.
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ACP Journal Club. What does it take to put an ugly fact through the heart of a beautiful hypothesis?
Ann Intern Med. 2009 Mar 17;150(6):JC3-2, JC3-3. doi: 10.7326/0003-4819-150-6-200903170-02002.
3
NSAIDs, risks, and gastroprotective strategies: current status and future.
Gastroenterology. 2008 Apr;134(4):1240-6. doi: 10.1053/j.gastro.2008.02.007.
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Celecoxib compared with lansoprazole and naproxen to prevent gastrointestinal ulcer complications.
Am J Med. 2005 Nov;118(11):1271-8. doi: 10.1016/j.amjmed.2005.04.031.
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Gastroenterology. 2005 Mar;128(3):807; author reply 807--8. doi: 10.1053/j.gastro.2005.01.022.
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Surrogate endpoints and FDA's accelerated approval process.
Health Aff (Millwood). 2005 Jan-Feb;24(1):67-78. doi: 10.1377/hlthaff.24.1.67.

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