血液中过氧化氢酶活性低与四氧嘧啶引起的糖尿病有关。
Low catalase activity in blood is associated with the diabetes caused by alloxan.
作者信息
Takemoto Kazunori, Tanaka Miho, Iwata Hiroshi, Nishihara Ryou, Ishihara Kohji, Wang Da-Hong, Ogino Keiki, Taniuchi Koji, Masuoka Noriyoshi
机构信息
Kake Medical Science Education Center, Okayama, Japan.
出版信息
Clin Chim Acta. 2009 Sep;407(1-2):43-6. doi: 10.1016/j.cca.2009.06.028. Epub 2009 Jun 27.
BACKGROUND
Hydrogen peroxide is enzymatically processed by catalase, and catalase deficiency in blood is known as acatalasemia. We examined whether low catalase activity is a risk factor for diabetes mellitus.
METHODS
Blood glucose, insulin and glucose tolerance test were examined in acatalasemic and normal mice under non-stress and oxidative stress conditions. Alloxan administration was used as oxidative stress.
RESULTS
Alloxan, which was a drug that caused diabetes mellitus, mostly generated hydrogen peroxide by the reaction of alloxan and reduced glutathione, in vitro. Incidence of hyperglycemia in alloxan-untreated acatalasemic mice was as low as that in the normal mice. However, the incidence of acatalasemia mice treated with alloxan was higher than that in normal mice, and the number of pancreatic beta-cells in the acatalasemic mice was less than that in normal mice.
CONCLUSION
These results indicate that low catalase activity in the blood is associated with the diabetes mellitus caused by alloxan administration.
背景
过氧化氢由过氧化氢酶进行酶促处理，血液中过氧化氢酶缺乏被称为无过氧化氢酶血症。我们研究了低过氧化氢酶活性是否是糖尿病的一个危险因素。
方法
在非应激和氧化应激条件下，对无过氧化氢酶血症小鼠和正常小鼠进行血糖、胰岛素及葡萄糖耐量试验。使用四氧嘧啶给药作为氧化应激。
结果
四氧嘧啶是一种可导致糖尿病的药物，在体外，四氧嘧啶与还原型谷胱甘肽反应大多会生成过氧化氢。未用四氧嘧啶处理的无过氧化氢酶血症小鼠的高血糖发生率与正常小鼠一样低。然而，用四氧嘧啶处理的无过氧化氢酶血症小鼠的发生率高于正常小鼠，且无过氧化氢酶血症小鼠的胰腺β细胞数量少于正常小鼠。
结论
这些结果表明，血液中低过氧化氢酶活性与四氧嘧啶给药所致的糖尿病有关。
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