轮状病毒与澳大利亚内陆地区的原住民儿童：单价疫苗在高负担环境中有效。
Rotavirus and the indigenous children of the Australian outback: monovalent vaccine effective in a high-burden setting.
作者信息
Snelling Thomas L, Schultz Rosalie, Graham Julie, Roseby Robert, Barnes Graeme L, Andrews Ross M, Carapetis Jonathan R
机构信息
Menzies School of Health Research and Charles Darwin University, Darwin, Australia.
出版信息
Clin Infect Dis. 2009 Aug 1;49(3):428-31. doi: 10.1086/600395.
Indigenous children living in arid Central Australia experience frequent outbreaks of rotavirus gastroenteritis. A widespread outbreak of G9 rotavirus infection occurred several months after introduction of the RIX4414 rotavirus vaccine. We performed a retrospective case-control study to determine vaccine efficacy during the outbreak. Two doses provided an estimated vaccine efficacy of 77.7% (95% confidence interval, 40.2%-91.7%) against hospitalization for gastroenteritis. Vaccine efficacy was 84.5% (95% confidence interval, 23.4%-96.9%) against confirmed cases of rotavirus infection. Vaccination was effective in this high-burden setting.
生活在澳大利亚中部干旱地区的原住民儿童经常爆发轮状病毒肠胃炎。在引入RIX4414轮状病毒疫苗几个月后，发生了G9轮状病毒感染的广泛爆发。我们进行了一项回顾性病例对照研究，以确定疫情期间疫苗的效力。两剂疫苗对因肠胃炎住院的估计效力为77.7%（95%置信区间，40.2%-91.7%）。对确诊的轮状病毒感染病例，疫苗效力为84.5%（95%置信区间，23.4%-96.9%）。在这种高负担环境中，接种疫苗是有效的。
Zotero 插件