帕金森病患者中用于丘脑底核定位的深部脑刺激电极现场电位记录的频谱分析
Spectral analysis of field potential recordings by deep brain stimulation electrode for localization of subthalamic nucleus in patients with Parkinson's disease.
作者信息
Miyagi Yasushi, Okamoto Tsuyoshi, Morioka Takato, Tobimatsu Shozo, Nakanishi Yoshitaka, Aihara Kazuyuki, Hashiguchi Kimiaki, Murakami Nobuya, Yoshida Fumiaki, Samura Kazuhiro, Nagata Shinji, Sasaki Tomio
机构信息
Division of Digital Patient, Digital Medicine Initiative, Kyushu University, Higashi-ku, Fukuoka, Japan.
出版信息
Stereotact Funct Neurosurg. 2009;87(4):211-8. doi: 10.1159/000225974. Epub 2009 Jun 26.
AIMS
Spectral analysis of local field potential (LFP) recorded by deep brain stimulation (DBS) electrode around the subthalamic nucleus (STN) in patients with Parkinson's disease was performed.
METHODS
The borders of the STN were determined by microelectrode recording. The most eligible trajectory for the sensorimotor area of the STN was used for LFP recording while advancing the DBS electrode.
RESULTS
The low-frequency LFP power (theta- to beta-band) increased from a few millimeters above the dorsal border of the STN defined by microelectrode recording; however, the low-frequency power kept the same level beyond the ventral border of the STN. Only high beta-power showed close correlation to the dorsal and ventral borders of the STN.
CONCLUSIONS
A spectral power analysis of LFP recording by DBS electrode helps with the final confirmation of the dorsal and ventral borders of the STN of Parkinson's disease in DBS implantation surgery.
目的
对帕金森病患者丘脑底核（STN）周围深部脑刺激（DBS）电极记录的局部场电位（LFP）进行频谱分析。
方法
通过微电极记录确定STN的边界。在推进DBS电极时，将STN感觉运动区最适合的轨迹用于LFP记录。
结果
低频LFP功率（θ波至β波频段）从微电极记录定义的STN背侧边界上方几毫米处开始增加；然而，低频功率在STN腹侧边界之外保持相同水平。只有高β功率与STN的背侧和腹侧边界密切相关。
结论
DBS电极记录的LFP频谱功率分析有助于在DBS植入手术中最终确认帕金森病患者STN的背侧和腹侧边界。
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