与1918年和2009年全球大流行相关的两种甲型流感病毒株的血凝素和神经氨酸酶匹配模式。
Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics.
作者信息
Zhang Yonghui, Lin Xiaojing, Zhang Fengwei, Wu Jia, Tan Wenjie, Bi Shengli, Zhou Jianfang, Shu Yuelong, Wang Yue
机构信息
State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Xuanwu District, Beijing 100052, PR China.
出版信息
Biochem Biophys Res Commun. 2009 Sep 18;387(2):405-8. doi: 10.1016/j.bbrc.2009.07.040. Epub 2009 Jul 15.
The current pandemic influenza A (H1N1) virus has revealed a complicated reassortment of various influenza A viruses. The biological study of these viruses, especially of the viral envelope proteins hemagglutinin (HA) and neuraminidase (NA), is urgently needed for the control and prevention of H1N1 viruses. We have generated H1N1-2009 and H1N1-1918 pseudotyped particles (pp) with high infectivity. Combinations of HA1918+NA2009 and HA2009+NA1918 also formed infectious H1N1pps, among which the HA2009+NA1918 combination resulted in the most highly infectious pp. Our study demonstrated that some reassortments of H1N1 viruses may hold the potential to produce higher infectivity than do their ancestors.
当前的甲型H1N1流感大流行病毒显示出各种甲型流感病毒的复杂重配情况。对这些病毒进行生物学研究，尤其是对病毒包膜蛋白血凝素（HA）和神经氨酸酶（NA）的研究，对于控制和预防H1N1病毒来说迫在眉睫。我们已经制备出具有高感染性的2009年H1N1和1918年H1N1假型颗粒（pp）。HA1918 + NA2009和HA2009 + NA1918的组合也形成了具有感染性的H1N1假型颗粒，其中HA2009 + NA1918组合产生的假型颗粒感染性最强。我们的研究表明，H1N1病毒的某些重配可能具有产生比其祖先更高感染性的潜力。
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