CD4(+)CD25(high)CD127(low/-)调节性T细胞在移行细胞癌患者中的表达及其意义。
Expression of CD4(+)CD25(high)CD127(low/-) regulatory T cells in transitional cell carcinoma patients and its significance.
作者信息
Zhu Xi, Ma Lin-Lin, Ye Tian
机构信息
Department of Urology, Friendship Hospital, Capital Medical University, Beijing 100050, China.
出版信息
J Clin Lab Anal. 2009;23(4):197-201. doi: 10.1002/jcla.20331.
To evaluate the expressions of CD4(+)CD25(high)CD127(low/-) regulatory T cells (Tregs) in peripheral blood from patients with transitional cell carcinoma (TCC) in urinary system, we investigated the proportion of Treg population in CD4(+) T from 93 patients with TCC, 38 with benign urinary diseases, and 37 healthy subjects by using flow cytometric analysis and analyzing different clinicopathologic characteristics and the changes before and after operation. We found that the proportion of Treg in peripheral blood from patients with TCC was significantly increased as compared with the other two groups. There was a strong correlation between the proportion of Treg and tumor recurrence, quantity, lymph node metastasis (P<0.01), as well as pathological stage; no correlation was found between the proportion of Treg and clinical TNM stage (P>0.05). The proportion of Treg was also different before and after operation (P<0.05). This suggest that CD4(+)CD25(+)CD127(low/-) regulatory T cells may be responsible for immune suppression in TCC patients. The resection of tumor can decrease the proportion of Treg in peripheral blood.
为评估泌尿系统移行细胞癌（TCC）患者外周血中CD4(+)CD25(high)CD127(low/-)调节性T细胞（Tregs）的表达情况，我们采用流式细胞术分析，调查了93例TCC患者、38例良性泌尿系统疾病患者及37例健康受试者CD4(+)T细胞中Treg群体的比例，并分析了不同的临床病理特征及手术前后的变化。我们发现，与其他两组相比，TCC患者外周血中Treg的比例显著增加。Treg比例与肿瘤复发、数量、淋巴结转移（P<0.01）以及病理分期之间存在强相关性；未发现Treg比例与临床TNM分期之间存在相关性（P>0.05）。手术前后Treg比例也有所不同（P<0.05）。这表明CD4(+)CD25(+)CD127(low/-)调节性T细胞可能是TCC患者免疫抑制的原因。肿瘤切除可降低外周血中Treg的比例。
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