硝酰阴离子——内源性一氧化氮的通用信号伴侣？
Nitroxyl anion--the universal signalling partner of endogenously produced nitric oxide?
作者信息
Martin William
机构信息
Integrative & Systems Biology, Faculty of Biomedical & Life Sciences, University of Glasgow, Glasgow, UK.
出版信息
Br J Pharmacol. 2009 Jun;157(4):537-9. doi: 10.1111/j.1476-5381.2009.00153.x.
Abstract
Although it is generally assumed that the primary product of the three isoforms of NO synthase is the nitric oxide radical (NO()), growing evidence suggests that the one-electron reduced form of nitrogen monoxide, nitroxyl anion (NO(-)), may be a natural co-product. Thus, evidence from conduit and resistance arteries and nitrergically innervated tissues indicates that NO(-) exerts widespread signalling functions alongside NO() in the cardiovascular and autonomic nervous systems, and perhaps beyond. In this issue of the BJP Andrews et al. add to this debate by providing strong evidence that NO(*) and HNO both contribute to the EDRF-mediated component of in mouse (MMA) and rat (RMA) mesenteric resistance arteries.
摘要
尽管一般认为一氧化氮合酶三种同工型的主要产物是一氧化氮自由基（NO()），但越来越多的证据表明，一氧化氮的单电子还原形式硝酰阴离子（NO(-)）可能是一种天然的副产物。因此，来自导管和阻力动脉以及有氮能神经支配组织的证据表明，在心血管和自主神经系统中，或许还不止于此，NO(-)与NO()一起发挥着广泛的信号传导功能。在本期《英国药理学杂志》中，安德鲁斯等人通过提供有力证据，即NO(*)和HNO都对小鼠（MMA）和大鼠（RMA）肠系膜阻力动脉中内皮依赖性舒张因子（EDRF）介导的成分有贡献，从而加入了这场争论。
相似文献
1
Nitroxyl anion--the universal signalling partner of endogenously produced nitric oxide?硝酰阴离子——内源性一氧化氮的通用信号伴侣？
Br J Pharmacol. 2009 Jun;157(4):537-9. doi: 10.1111/j.1476-5381.2009.00153.x.
2
A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries.硝酰（HNO）作为阻力动脉中一种内皮源性舒张和超极化因子的作用。
Br J Pharmacol. 2009 Jun;157(4):540-50. doi: 10.1111/j.1476-5381.2009.00150.x. Epub 2009 Mar 26.
3
Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice.硝普阴离子介导血管紧张素 II 高血压小鼠肠系膜动脉的舒张。
Curr Vasc Pharmacol. 2017;16(1):93-101. doi: 10.2174/1570161115666170725151509.
4
Nitroxyl (HNO) as a vasoprotective signaling molecule.硝普盐（HNO）作为一种血管保护信号分子。
Antioxid Redox Signal. 2011 May 1;14(9):1675-86. doi: 10.1089/ars.2010.3327. Epub 2010 Nov 2.
5
[Superoxide anion inhibit endothelium-dependent relaxation in rat mesenteric artery].[超氧阴离子抑制大鼠肠系膜动脉的内皮依赖性舒张]
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2008 Aug;24(3):363-6.
6
Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm.氧化还原伙伴硝酰基和一氧化氮在心血管系统中的正交特性：一种新的氧化还原模式。
Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2264-76. doi: 10.1152/ajpheart.00531.2003. Epub 2003 Jul 10.
7
Vasoactive actions of nitroxyl (HNO) are preserved in resistance arteries in diabetes.糖尿病患者的阻力动脉中硝酰基（HNO）的血管活性作用得以保留。
Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr;390(4):397-408. doi: 10.1007/s00210-016-1336-1. Epub 2017 Jan 10.
8
Endothelium-dependent vasodilation in human mesenteric artery is primarily mediated by myoendothelial gap junctions intermediate conductance calcium-activated K+ channel and nitric oxide.人类肠系膜动脉中的内皮依赖性血管舒张主要由肌内皮缝隙连接中介电导钙激活钾通道和一氧化氮介导。
J Pharmacol Exp Ther. 2011 Mar;336(3):701-8. doi: 10.1124/jpet.110.165795. Epub 2010 Dec 20.
9
Endothelium-derived relaxing factor-mediated vasodilation in mouse mesenteric vascular beds.内皮衍生的舒张因子介导的小鼠肠系膜血管床血管舒张。
J Pharmacol Sci. 2012;118(3):373-81. doi: 10.1254/jphs.11197fp.
10
Gender specific generation of nitroxyl (HNO) from rat endothelium.大鼠内皮细胞中性别特异性的硝酰基（HNO）生成
Vascul Pharmacol. 2015 Aug;71:208-14. doi: 10.1016/j.vph.2015.03.004. Epub 2015 Apr 11.
引用本文的文献
1
Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta.Angeli's Salt，一种硝酮阴离子供体，可逆转内皮素-1 介导的小鼠主动脉血管功能障碍。
Eur J Pharmacol. 2017 Nov 5;814:294-301. doi: 10.1016/j.ejphar.2017.08.024. Epub 2017 Aug 20.
2
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation.活性氧和氮物种在炎症血管反应中的作用。
Free Radic Biol Med. 2012 Feb 1;52(3):556-592. doi: 10.1016/j.freeradbiomed.2011.11.002. Epub 2011 Nov 12.
3
Endothelium-derived hyperpolarising factors and associated pathways: a synopsis.内皮衍生超极化因子及相关途径：概述。
Pflugers Arch. 2010 May;459(6):863-79. doi: 10.1007/s00424-010-0817-1. Epub 2010 Apr 11.
4
Robert F. Furchgott, Nobel laureate (1916-2009)--a personal reflection.罗伯特·F·弗奇戈特，诺贝尔奖得主（1916-2009）——个人反思。
Br J Pharmacol. 2009 Oct;158(3):633-7. doi: 10.1111/j.1476-5381.2009.00418.x. Epub 2009 Aug 13.
5
Endothelium in pharmacology: 30 years on.药理学中的内皮细胞：三十年回顾。
Br J Pharmacol. 2009 Jun;157(4):491-3. doi: 10.1111/j.1476-5381.2009.00366.x.
本文引用的文献
1
A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries.硝酰（HNO）作为阻力动脉中一种内皮源性舒张和超极化因子的作用。
Br J Pharmacol. 2009 Jun;157(4):540-50. doi: 10.1111/j.1476-5381.2009.00150.x. Epub 2009 Mar 26.
2
Nitroxyl (HNO): the Cinderella of the nitric oxide story.硝酰基（HNO）：一氧化氮故事中的灰姑娘。
Trends Pharmacol Sci. 2008 Dec;29(12):601-8. doi: 10.1016/j.tips.2008.08.005. Epub 2008 Oct 1.
3
Examining nitroxyl in biological systems.研究生物系统中的硝酰基。
Methods Enzymol. 2008;440:411-31. doi: 10.1016/S0076-6879(07)00826-9.
4
NO- activates soluble guanylate cyclase and Kv channels to vasodilate resistance arteries.一氧化氮激活可溶性鸟苷酸环化酶和钾离子通道，使阻力动脉血管舒张。
Hypertension. 2003 Jun;41(6):1301-7. doi: 10.1161/01.HYP.0000072010.54901.DE. Epub 2003 May 12.
5
Vascular smooth muscle relaxation mediated by nitric oxide donors: a comparison with acetylcholine, nitric oxide and nitroxyl ion.一氧化氮供体介导的血管平滑肌舒张：与乙酰胆碱、一氧化氮和硝酰离子的比较。
Br J Pharmacol. 2001 Oct;134(3):463-72. doi: 10.1038/sj.bjp.0704269.
6
Differential actions of L-cysteine on responses to nitric oxide, nitroxyl anions and EDRF in the rat aorta.L-半胱氨酸对大鼠主动脉中一氧化氮、硝酰阴离子和内皮舒张因子反应的不同作用。
Br J Pharmacol. 2000 Jan;129(2):315-22. doi: 10.1038/sj.bjp.0703058.
7
Comparison of the redox forms of nitrogen monoxide with the nitrergic transmitter in the rat anococcygeus muscle.大鼠肛门尾骨肌中一氧化氮的氧化还原形式与含氮能递质的比较。
Br J Pharmacol. 1999 Jun;127(4):826-34. doi: 10.1038/sj.bjp.0702540.
8
Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery.一氧化氮是家兔颈动脉内皮依赖性舒张和超极化的介质。
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4193-8. doi: 10.1073/pnas.94.8.4193.
9
Nitric oxide (NO), the only nitrogen monoxide redox form capable of activating soluble guanylyl cyclase.一氧化氮（NO），唯一能够激活可溶性鸟苷酸环化酶的一氧化氮氧化还原形式。
Biochem Pharmacol. 1996 Jun 28;51(12):1593-600. doi: 10.1016/0006-2952(96)00078-0.
10
Bioassay discrimination between nitric oxide (NO.) and nitroxyl (NO-) using L-cysteine.使用L-半胱氨酸对一氧化氮（NO.）和硝酰基（NO-）进行生物测定鉴别
Biochem Biophys Res Commun. 1994 May 30;201(1):54-62. doi: 10.1006/bbrc.1994.1668.
Zotero 插件