硝酰阴离子——内源性一氧化氮的通用信号伴侣？
Nitroxyl anion--the universal signalling partner of endogenously produced nitric oxide?
作者信息
Martin William
机构信息
Integrative & Systems Biology, Faculty of Biomedical & Life Sciences, University of Glasgow, Glasgow, UK.
出版信息
Br J Pharmacol. 2009 Jun;157(4):537-9. doi: 10.1111/j.1476-5381.2009.00153.x.
Although it is generally assumed that the primary product of the three isoforms of NO synthase is the nitric oxide radical (NO()), growing evidence suggests that the one-electron reduced form of nitrogen monoxide, nitroxyl anion (NO(-)), may be a natural co-product. Thus, evidence from conduit and resistance arteries and nitrergically innervated tissues indicates that NO(-) exerts widespread signalling functions alongside NO() in the cardiovascular and autonomic nervous systems, and perhaps beyond. In this issue of the BJP Andrews et al. add to this debate by providing strong evidence that NO(*) and HNO both contribute to the EDRF-mediated component of in mouse (MMA) and rat (RMA) mesenteric resistance arteries.
尽管一般认为一氧化氮合酶三种同工型的主要产物是一氧化氮自由基（NO()），但越来越多的证据表明，一氧化氮的单电子还原形式硝酰阴离子（NO(-)）可能是一种天然的副产物。因此，来自导管和阻力动脉以及有氮能神经支配组织的证据表明，在心血管和自主神经系统中，或许还不止于此，NO(-)与NO()一起发挥着广泛的信号传导功能。在本期《英国药理学杂志》中，安德鲁斯等人通过提供有力证据，即NO(*)和HNO都对小鼠（MMA）和大鼠（RMA）肠系膜阻力动脉中内皮依赖性舒张因子（EDRF）介导的成分有贡献，从而加入了这场争论。
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