利钠肽在慢性心力衰竭的诊断与管理中的应用
Natriuretic peptides in the diagnosis and management of chronic heart failure.
作者信息
Boerrigter Guido, Costello-Boerrigter Lisa C, Burnett John C
机构信息
Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
出版信息
Heart Fail Clin. 2009 Oct;5(4):501-14. doi: 10.1016/j.hfc.2009.04.002.
Abstract
Circulating levels of the BNP system can help in the diagnosis of cardiovascular disease and provide prognostic information not only for patients who have HF but also for the general population and other patient groups. Changes over time also carry prognostic information, and studies are assessing BNP-guided treatment strategies. With the identification of circulating molecular forms of BNP, new insights regarding the biology of the BNP system are emerging that may improve the diagnostic and prognostic value of BNP. Likewise, accounting for rs198389 (a common single nucleotide polymorphism that increases BNP levels) may help to further refine the use of components of the BNP system as biomarkers.
摘要
BNP系统的循环水平有助于心血管疾病的诊断，不仅可为心力衰竭患者，也可为普通人群和其他患者群体提供预后信息。随时间的变化也携带预后信息，并且研究正在评估以BNP为指导的治疗策略。随着循环中BNP分子形式的鉴定，关于BNP系统生物学的新见解正在出现，这可能会提高BNP的诊断和预后价值。同样，考虑rs198389（一种增加BNP水平的常见单核苷酸多态性）可能有助于进一步优化将BNP系统的组成部分用作生物标志物的应用。
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Only large reductions in concentrations of natriuretic peptides (BNP and NT-proBNP) are associated with improved outcome in ambulatory patients with chronic heart failure.仅利钠肽（脑钠肽和N末端脑钠肽原）浓度的大幅降低与慢性心力衰竭门诊患者预后改善相关。
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