取代吡唑、异噁唑、嘧啶和噻嘧啶衍生物的合成、抗菌和抗氧化活性。
Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives.
机构信息
Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
出版信息
Eur J Med Chem. 2009 Nov;44(11):4557-66. doi: 10.1016/j.ejmech.2009.06.024. Epub 2009 Jun 28.
PMID:19631423
Abstract
A new class of heterocycles, substituted pyrazoles, isoxazoles, pyrimidines, thioxopyrimidines were prepared from Michael adducts, 2-(1,2-diaroylethyl)malononitrile and 2-(1,2-diarylsulfonylethyl)malononitrile by cyclocondensation with appropriate nucleophiles. The lead compounds were screened for the antimicrobial and antioxidant activities.
摘要
一类新的杂环化合物，包括取代的吡唑、异噁唑、嘧啶、噻吩并嘧啶，是由迈克尔加成物 2-（1,2-二芳基乙基亚磺酰基）丙二腈和 2-（1,2-二芳基乙基亚磺酰基）丙二腈与适当的亲核试剂环缩合得到的。对这些先导化合物进行了抗菌和抗氧化活性筛选。
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