[青少年群体中甲型肝炎病毒流行过程的发展及体液免疫的形成]
[The development of the epidemic process and the formation of humoral immunity to the hepatitis A virus in adolescent collectives].
作者信息
Karetnyĭ Iu V, Vasil'eva Z N, Balaian M S, Zenkov V A, Sysoliatin V A, Sobina G V, Lysenko G V, Tsvetova G V, Tesheva S Ch, Klimenko L A
出版信息
Zh Mikrobiol Epidemiol Immunobiol. 1990 Oct(10):71-6.
Additional observation on the formation of humoral immunity to hepatitis A virus has been carried out in 2,375 adolescents aged 15-17 years and belonging to 12 groups at 3 areas of the USSR. This observation has shown that in the presence of a high level of the immune stratum the spread of infection occurs, as a rule, outside the group under observation. Besides, as revealed in this study, the risk of seroconversion and the loss of specific antibodies are, respectively, directly and inversely related to the level of the immune stratum in the group. The level of the immune stratum in a given age group supposedly reflects the intensity of the development of the epidemic process at a definite area.
在苏联3个地区，对2375名年龄在15至17岁、分属12个组的青少年进行了关于甲型肝炎病毒体液免疫形成的补充观察。该观察表明，在免疫阶层水平较高的情况下，感染通常在观察组之外传播。此外，本研究还发现，血清转化风险和特异性抗体丧失分别与组内免疫阶层水平呈直接和反向相关。特定年龄组的免疫阶层水平据推测反映了特定地区流行过程的发展强度。
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