Cherry Simon R
Department of Biomedical Engineering, Center for Molecular and Genomic Imaging, University of California-Davis, Davis, CA 95616, USA.
Semin Nucl Med. 2009 Sep;39(5):348-53. doi: 10.1053/j.semnuclmed.2009.03.001.
Multimodality imaging with positron emission tomography/computed tomography (PET/CT) and single-photon emission computed tomography (SPECT)/CT has become commonplace in clinical practice and in preclinical and basic biomedical research. Do other combinations of imaging modalities have a similar potential to impact medical science and clinical medicine? Presently, the combination of PET or SPECT with magnetic resonance imaging (MRI) is an area of active research, while other, perhaps less obvious combinations, including CT/MRI and PET/optical also are being studied. In addition to the integration of the instrumentation, there are parallel developments in synthesizing imaging agents that can be viewed by multiple imaging modalities. Is the fusion of PET and SPECT with CT the ultimate answer in multimodality imaging, or is it just the first example of a more general trend toward harnessing the complementary nature of the different modalities on integrated imaging platforms?
正电子发射断层扫描/计算机断层扫描(PET/CT)和单光子发射计算机断层扫描(SPECT/CT)的多模态成像在临床实践以及临床前和基础生物医学研究中已变得很常见。其他成像模态的组合是否有类似的潜力来影响医学科学和临床医学呢?目前,PET或SPECT与磁共振成像(MRI)的组合是一个活跃的研究领域,而其他可能不太明显的组合,包括CT/MRI和PET/光学成像也正在被研究。除了仪器设备的整合之外,在合成可被多种成像模态观察的成像剂方面也有并行的进展。PET和SPECT与CT的融合是多模态成像的最终答案吗,还是它仅仅是在集成成像平台上利用不同模态互补特性这一更普遍趋势的第一个例子呢?