Fumagalli Marzia, d'Adda di Fagagna Fabrizio
Marzia Fumagalli and Fabrizio d'Adda di Fagagna are at the IFOM Foundation - FIRC Institute of Molecular Oncology Foundation, via Adamello 16, 20139 Milan, Italy.
Nat Cell Biol. 2009 Aug;11(8):921-3. doi: 10.1038/ncb0809-921.
Senescent cells alter their microenvironment by secreting a growing collection of factors, a phenomenon termed the senescence-associated secretory phenotype (SASP). Cellular senescence is often the result of nuclear DNA damage fuelling a chronic DNA damage response (DDR). Upstream elements of the DDR cascade are necessary for full blown SASP, and additional crosstalk occurs between the DDR and cytokine secretion.
衰老细胞通过分泌越来越多的因子来改变其微环境，这一现象被称为衰老相关分泌表型（SASP）。细胞衰老通常是核DNA损伤引发慢性DNA损伤反应（DDR）的结果。DDR级联反应的上游元件对于完全形成SASP是必需的，并且在DDR和细胞因子分泌之间还存在额外的相互作用。
