黄素蛋白介导的胺类氧化。
Oxidation of amines by flavoproteins.
机构信息
Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA.
出版信息
Arch Biochem Biophys. 2010 Jan 1;493(1):13-25. doi: 10.1016/j.abb.2009.07.019. Epub 2009 Aug 3.
Abstract
Many flavoproteins catalyze the oxidation of primary and secondary amines, with the transfer of a hydride equivalent from a carbon-nitrogen bond to the flavin cofactor. Most of these amine oxidases can be classified into two structural families, the D-amino acid oxidase/sarcosine oxidase family and the monoamine oxidase family. This review discusses the present understanding of the mechanisms of amine and amino acid oxidation by flavoproteins, focusing on these two structural families.
摘要
许多黄素蛋白催化伯胺和仲胺的氧化，将氢原子从碳-氮键转移到黄素辅因子。这些胺氧化酶大多数可以分为两个结构家族，即 D-氨基酸氧化酶/肌氨酸氧化酶家族和单胺氧化酶家族。本文讨论了目前对黄素蛋白催化胺和氨基酸氧化机制的理解，重点介绍了这两个结构家族。
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