胰管支架直径对慢性胰腺炎住院的影响：支架大小重要吗？

Effect of pancreatic duct stent diameter on hospitalization in chronic pancreatitis: does size matter?

机构信息

Department of Medicine, University of Virginia, Charlottesville, USA.

出版信息

Pancreas. 2009 Oct;38(7):728-31. doi: 10.1097/MPA.0b013e3181b2bd45.

DOI:10.1097/MPA.0b013e3181b2bd45

PMID:19657308

Abstract

OBJECTIVE

Endoscopic therapy with pancreatic duct (PD) stenting in painful chronic pancreatitis is effective at reducing pain. Few studies have compared response to different PD stent diameters. In this study, we retrospectively analyzed the effect of PD stent diameter on hospitalization for abdominal pain in chronic pancreatitis.

METHODS

An existing database was queried to identify individuals who received PD stenting for chronic pancreatitis. Each patient was grouped according to stent diameter: (1) 8.5F stents or smaller and (2) 10F stents. The main outcome was number of hospitalizations adjusting for varying follow-up time and controlling for age, sex, and etiology of pancreatitis using a negative binomial model.

RESULTS

One hundred sixty-three patients underwent PD stent placement for chronic pancreatitis from October 1995 to September 2007. One hundred twenty-nine patients (79%) received predominantly PD stents 8.5F or smaller in diameter, and 34 patients (21%) received predominantly PD stents 10F in diameter. There was no statistically significant difference in population characteristics between the 2 groups. The 10F stent group had a statistically significant (P = 0.003) lower rate of hospitalization.

CONCLUSIONS

Patients who received larger diameter PD stents had fewer hospitalizations for abdominal pain. Outcome-based prospective studies are needed.

摘要

目的

内镜下胰管（PD）支架置入术治疗慢性胰腺炎疼痛有效，可减轻疼痛。少数研究比较了不同 PD 支架直径的反应。本研究回顾性分析 PD 支架直径对慢性胰腺炎腹痛住院的影响。

方法

查询现有数据库以确定因慢性胰腺炎接受 PD 支架置入术的个体。根据支架直径将每位患者分为两组：（1）8.5F 支架或更小，（2）10F 支架。主要结果是调整不同随访时间后因年龄、性别和胰腺炎病因使用负二项模型调整的住院次数。

结果

1995 年 10 月至 2007 年 9 月，163 例患者因慢性胰腺炎接受 PD 支架置入术。129 例（79%）患者主要接受 8.5F 或更小直径的 PD 支架，34 例（21%）患者主要接受 10F 直径的 PD 支架。两组人群特征无统计学差异。10F 支架组的住院率明显较低（P=0.003）。