呼吸道合胞病毒感染相关急性中耳炎的临床特征

Clinical characteristics of respiratory syncytial virus infection-associated acute otitis media.

作者信息

Tomochika Kiyoko, Ichiyama Takashi, Shimogori Hiroaki, Sugahara Kazuma, Yamashita Hiroshi, Furukawa Susumu

机构信息

Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.

出版信息

Pediatr Int. 2009 Aug;51(4):484-7. doi: 10.1111/j.1442-200X.2008.02768.x.

DOI:10.1111/j.1442-200X.2008.02768.x

PMID:19674360

Abstract

BACKGROUND

It is known that children with respiratory syncytial virus (RSV) infection frequently have complications of acute otitis media (AOM).

METHODS

The hospital records of 148 inpatients aged 6-35 months who had RSV infection between January 2004 and December 2007, were retrospectively investigated.

RESULTS

Forty-six out of 148 children (31%) had AOM. There was a significantly greater number of children with fever who had AOM (P = 0.005). The percentage of children with beta-lactamase-non-producing ampicillin-resistant (BLNAR) Haemophilus influenzae in nasopharyngeal culture who had AOM showed a tendency to be greater than that of those who did not have AOM, but this was not statistically significant (P = 0.068). Moreover, BLNAR H. influenzae was positive in middle ear fluid specimens from four of five children with AOM who underwent tympanocentesis. There were no significant differences in the incidence of lower airway infection, leukocytes counts, or serum C-reactive protein levels between children with and without AOM.

CONCLUSIONS

Children who had RSV infection with AOM had a higher incidence of fever than those without AOM.

摘要

背景

已知呼吸道合胞病毒（RSV）感染的儿童经常并发急性中耳炎（AOM）。

方法

回顾性调查了2004年1月至2007年12月期间148例年龄在6至35个月之间的RSV感染住院患者的医院记录。

结果

148名儿童中有46名（31%）患有AOM。患有AOM的发热儿童数量明显更多（P = 0.005）。鼻咽培养中无β-内酰胺酶产生的氨苄西林耐药（BLNAR）流感嗜血杆菌的AOM儿童百分比有高于未患AOM儿童的趋势，但无统计学意义（P = 0.068）。此外，在接受鼓膜穿刺术的5名AOM儿童中，有4名儿童的中耳液标本中BLNAR流感嗜血杆菌呈阳性。患AOM和未患AOM的儿童在下呼吸道感染发生率、白细胞计数或血清C反应蛋白水平方面无显著差异。